Tumor-infiltrating lymphocytes: apparently good for melanoma patients. But why?

Tumor-infiltrating T lymphocytes (TILs) are observed in a number of human primary or metastatic tumors. Recently, gene expression profiling experiments suggested that the presence of T cells in metastatic melanomas before vaccinating the patients with tumor antigens could be a biomarker for clinical...

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Vydané v:	Cancer Immunology, Immunotherapy Ročník 60; číslo 8; s. 1153 - 1160
Hlavní autori:	Cipponi, Arcadi, Wieers, Grégoire, van Baren, Nicolas, Coulie, Pierre G.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Berlin/Heidelberg Springer-Verlag 01.08.2011 Springer Springer Nature B.V
Predmet:	Animals Antigens Antigens, Neoplasm - immunology Antineoplastic agents Biological and medical sciences Biomarkers Biomarkers, Pharmacological - metabolism Biopsy Cancer Cancer Research Cancer Vaccines Dermatology Focussed Research Review Gene expression Gene Expression Profiling Humans Immunization Immunology Immunotherapy Lymphatic system Lymphocytes Lymphocytes, Tumor-Infiltrating - immunology Medical prognosis Medical research Medical sciences Medicine Medicine & Public Health Melanoma Melanoma - diagnosis Melanoma - immunology Melanoma - pathology Metastasis Multivariate analysis Neoplasm Metastasis Oncology Patient Selection Patients Pharmacology. Drug treatments Prognosis Skin Neoplasms - diagnosis Skin Neoplasms - immunology Skin Neoplasms - pathology Tumors Tumors of the skin and soft tissue. Premalignant lesions Vaccines Belgium PIVAC 10 Prognosis T lymphocyte Immunotherapy Melanoma Human Patient Tumor infiltrating lymphocyte Malignant tumor Treatment T-Lymphocyte Malignant melanoma Cancer
ISSN:	0340-7004, 1432-0851, 1432-0851
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Shrnutí:	Tumor-infiltrating T lymphocytes (TILs) are observed in a number of human primary or metastatic tumors. Recently, gene expression profiling experiments suggested that the presence of T cells in metastatic melanomas before vaccinating the patients with tumor antigens could be a biomarker for clinical benefit from the vaccines. In this context, we review results pertaining to TILs in human melanomas, their prognostic value, and some possible reasons why their presence could help in selecting melanoma patients for vaccination against tumor-specific antigens.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	0340-7004 1432-0851 1432-0851
DOI:	10.1007/s00262-011-1026-2