Overexpression of the Endothelial Protein C Receptor Is Detrimental during Pneumonia-Derived Gram-negative Sepsis (Melioidosis)

The endothelial protein C receptor (EPCR) enhances anticoagulation by accelerating activation of protein C to activated protein C (APC) and mediates anti-inflammatory effects by facilitating APC-mediated signaling via protease activated receptor-1. We studied the role of EPCR in the host response du...

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Bibliographic Details
Published in:	PLoS neglected tropical diseases Vol. 7; no. 7; p. e2306
Main Authors:	Kager, Liesbeth M., Schouten, Marcel, Wiersinga, W. Joost, de Boer, J. Daan, Lattenist, Lionel C. W., Roelofs, Joris J. T. H., Meijers, Joost C. M., Levi, Marcel, Dondorp, Arjen M., Esmon, Charles T., van 't Veer, Cornelis, van der Poll, Tom
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 11.07.2013 Public Library of Science (PLoS)
Subjects:	Adolescent Adult Aged Aged, 80 and over Animals Anticoagulants Antigens, CD - blood Asia Asia, Southeastern Binding sites Biology Burkholderia Cytokines Disease Models, Animal Endothelial Protein C Receptor Experiments Female Grants Humans Male Medical research Medicine Melioidosis - pathology Mice Mice, Inbred C57BL Mice, Knockout Middle Aged Mortality Pathogenesis Plasma Pneumonia Pneumonia, Bacterial - complications Proteins Receptors, Cell Surface - blood Rodents Sepsis Sepsis - pathology Survival Analysis Young Adult Humans Mice, Inbred C57BL Middle Aged Pneumonia, Bacterial Male Receptors, Cell Surface Mice, Knockout Asia, Southeastern Melioidosis Young Adult Aged, 80 & over Animals Asia Adolescent Survival Analysis Adult Female Sepsis Aged Mice Antigens, CD Disease Models, Animal
ISSN:	1935-2735, 1935-2727, 1935-2735
Online Access:	Get full text
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