Depot-specific differences in inflammatory mediators and a role for NK cells and IFN-gamma in inflammation in human adipose tissue

Background: Adipose tissue is a primary in vivo site of inflammation in obesity. Excess visceral adipose tissue (VAT), when compared to subcutaneous adipose tissue (SAT), imparts an increased risk of obesity-related comorbidities and mortality, and exhibits differences in inflammation. Defining depo...

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Bibliographic Details
Published in:	International Journal of Obesity Vol. 33; no. 9; pp. 978 - 990
Main Authors:	O'Rourke, R.W, Metcalf M.D, White, A.E, Madala, A, Winters, B.R, Maizlin, I.I, Jobe, B.A, Roberts, C.T. Jr, Slifka, M.K, Marks, D.L
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.09.2009 Nature Publishing Group
Subjects:	adipose tissue Adipose tissues Adult Bariatric Surgery Biochemical assays Biological and medical sciences cytokines Diagnosis enzyme-linked immunosorbent assay Epidemiology Female flow cytometry Gene Expression Regulation Genetic transcription genetics Health Promotion and Disease Prevention Humans Immunohistochemistry in vitro studies Inflammation Inflammation Mediators Inflammation Mediators - metabolism interferon-gamma Interferon-gamma - genetics Interferon-gamma - metabolism interferons Internal Medicine Intra-Abdominal Fat Intra-Abdominal Fat - metabolism Killer Cells, Natural Killer Cells, Natural - metabolism macrophages Medical sciences Medicine Medicine & Public Health Metabolic Diseases metabolism Methods morbidity mortality natural killer cells Obesity Obesity - genetics Obesity - metabolism original-article Panniculitis Panniculitis - metabolism phenotype Properties Public Health stromovascular cell fractions Subcutaneous Fat Subcutaneous Fat - metabolism T-lymphocytes transcription factors women adipose tissue IFN-γ NK cells inflammation Human Obesity Adipose tissue Nutrition Nutrition disorder Metabolic diseases Inflammation Natural killer cell Mediator Nutritional status Comparative study Gamma interferon
ISSN:	0307-0565, 1476-5497, 1476-5497
Online Access:	Get full text
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