Evaluation of multi-echo ICA denoising for task based fMRI studies: Block designs, rapid event-related designs, and cardiac-gated fMRI

Multi-echo fMRI, particularly the multi-echo independent component analysis (ME-ICA) algorithm, has previously proven useful for increasing the sensitivity and reducing false positives for functional MRI (fMRI) based resting state connectivity studies. Less is known about its efficacy for task-based...

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Vydáno v:NeuroImage (Orlando, Fla.) Ročník 141; s. 452 - 468
Hlavní autoři: Gonzalez-Castillo, Javier, Panwar, Puja, Buchanan, Laura C., Caballero-Gaudes, Cesar, Handwerker, Daniel A., Jangraw, David C., Zachariou, Valentinos, Inati, Souheil, Roopchansingh, Vinai, Derbyshire, John A., Bandettini, Peter A.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Elsevier Inc 01.11.2016
Elsevier Limited
Témata:
Adult
Algorithms
Block design
Brain - physiology
Brain Mapping - methods
Cardiac-Gated Imaging Techniques - methods
Datasets
Experiments
Female
Functional magnetic resonance imaging
Heart
Heart diseases
Humans
Image Enhancement - methods
Image Interpretation, Computer-Assisted - methods
Magnetic Resonance Imaging - methods
Male
ME-ICA
Multi-echo fMRI
Neural networks
Noise
Physiology
Principal Component Analysis
Principal components analysis
Rapid event related
Repetition
Reproducibility of Results
Sensitivity
Sensitivity and Specificity
Signal-To-Noise Ratio
Task Performance and Analysis
Time series
Sensitivity
Rapid event related
Block design
Multi-echo fMRI
ME-ICA
ISSN:1053-8119, 1095-9572
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Shrnutí:Multi-echo fMRI, particularly the multi-echo independent component analysis (ME-ICA) algorithm, has previously proven useful for increasing the sensitivity and reducing false positives for functional MRI (fMRI) based resting state connectivity studies. Less is known about its efficacy for task-based fMRI, especially at the single subject level. This work, which focuses exclusively on individual subject results, compares ME-ICA to single-echo fMRI and a voxel-wise T2⁎ weighted combination of multi-echo data for task-based fMRI under the following scenarios: cardiac-gated block designs, constant repetition time (TR) block designs, and constant TR rapid event-related designs. Performance is evaluated primarily in terms of sensitivity (i.e., activation extent, activation magnitude, percent detected trials and effect size estimates) using five different tasks expected to evoke neuronal activity in a distributed set of regions. The ME-ICA algorithm significantly outperformed all other evaluated processing alternatives in all scenarios. Largest improvements were observed for the cardiac-gated dataset, where ME-ICA was able to reliably detect and remove non-neural T1 signal fluctuations caused by non-constant repetition times. Although ME-ICA also outperformed the other options in terms of percent detection of individual trials for rapid event-related experiments, only 46% of all events were detected after ME-ICA; suggesting additional improvements in sensitivity are required to reliably detect individual short event occurrences. We conclude the manuscript with a detailed evaluation of ME-ICA outcomes and a discussion of how the ME-ICA algorithm could be further improved. Overall, our results suggest that ME-ICA constitutes a versatile, powerful approach for advanced denoising of task-based fMRI, not just resting-state data. •Sensitivity for task-based fMRI experiments significantly improved with ME-ICA.•Observed improvements generalized across tasks and experimental designs.•ME-ICA reliably and robustly removed T1 artifacts in cardiac-gated fMRI datasets.•Several enhancements to further improve ME-ICA's performance are proposed.
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ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2016.07.049