The impact of diabetes on the pathogenesis of sepsis

Diabetes is associated with an increased susceptibility to infection and sepsis. Conflicting data exist on whether the mortality of patients with sepsis is influenced by the presence of diabetes, fuelling the ongoing debate on the benefit of tight glucose regulation in patients with sepsis. The main...

Full description

Saved in:
Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases Vol. 31; no. 4; pp. 379 - 388
Main Authors: Koh, G. C. K. W., Peacock, S. J., van der Poll, T., Wiersinga, W. J.
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer-Verlag 01.04.2012
Springer
Springer Nature B.V
Subjects:
Bacterial diseases
Bacterial sepsis
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Chemotaxis
Data processing
Defects
Diabetes
Diabetes Complications - immunology
Diabetes mellitus
Diabetes Mellitus - drug therapy
Diabetes. Impaired glucose tolerance
Disease Susceptibility
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Glucose
Hospitals
Human bacterial diseases
Humans
Hypoglycemic Agents - administration & dosage
Immune response
Immunity, Humoral
Infection
Infections
Infectious diseases
Insulin
Internal Medicine
Intracellular killing
Leukocytes (neutrophilic)
Medical Microbiology
Medical sciences
Medicine
Metformin
Mortality
Neutrophils
Neutrophils - immunology
Pathogenesis
Pneumonia
Population-based studies
Review
Sepsis
Sepsis - complications
Sepsis - mortality
thiazolidinediones
Tuberculosis
Tumor necrosis factor-TNF
United Kingdom > UK
Metformin
Glibenclamide
Intensive Insulin Therapy
Migration Inhibitory Factor
Otitis Externa
Endocrinopathy
Infection
Sepsis syndrome
Microbiology
Pathogenesis
Diabetes mellitus
Bacteriosis
Bacteremia
ISSN:0934-9723, 1435-4373, 1435-4373
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Diabetes is associated with an increased susceptibility to infection and sepsis. Conflicting data exist on whether the mortality of patients with sepsis is influenced by the presence of diabetes, fuelling the ongoing debate on the benefit of tight glucose regulation in patients with sepsis. The main reason for which diabetes predisposes to infection appears to be abnormalities of the host response, particularly in neutrophil chemotaxis, adhesion and intracellular killing, defects that have been attributed to the effect of hyperglycaemia. There is also evidence for defects in humoral immunity, and this may play a larger role than previously recognised. We review the literature on the immune response in diabetes and its potential contribution to the pathogenesis of sepsis. In addition, the effect of diabetes treatment on the immune response is discussed, with specific reference to insulin, metformin, sulphonylureas and thiazolidinediones.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 14
ObjectType-Article-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:0934-9723
1435-4373
1435-4373
DOI:10.1007/s10096-011-1337-4