The impact of diabetes on the pathogenesis of sepsis

Diabetes is associated with an increased susceptibility to infection and sepsis. Conflicting data exist on whether the mortality of patients with sepsis is influenced by the presence of diabetes, fuelling the ongoing debate on the benefit of tight glucose regulation in patients with sepsis. The main...

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Vydáno v:	European journal of clinical microbiology & infectious diseases Ročník 31; číslo 4; s. 379 - 388
Hlavní autoři:	Koh, G. C. K. W., Peacock, S. J., van der Poll, T., Wiersinga, W. J.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Berlin/Heidelberg Springer-Verlag 01.04.2012 Springer Springer Nature B.V
Témata:	Bacterial diseases Bacterial sepsis Biological and medical sciences Biomedical and Life Sciences Biomedicine Chemotaxis Data processing Defects Diabetes Diabetes Complications - immunology Diabetes mellitus Diabetes Mellitus - drug therapy Diabetes. Impaired glucose tolerance Disease Susceptibility Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Glucose Hospitals Human bacterial diseases Humans Hypoglycemic Agents - administration & dosage Immune response Immunity, Humoral Infection Infections Infectious diseases Insulin Internal Medicine Intracellular killing Leukocytes (neutrophilic) Medical Microbiology Medical sciences Medicine Metformin Mortality Neutrophils Neutrophils - immunology Pathogenesis Pneumonia Population-based studies Review Sepsis Sepsis - complications Sepsis - mortality thiazolidinediones Tuberculosis Tumor necrosis factor-TNF United Kingdom > UK Metformin Glibenclamide Intensive Insulin Therapy Migration Inhibitory Factor Otitis Externa Endocrinopathy Infection Sepsis syndrome Microbiology Pathogenesis Diabetes mellitus Bacteriosis Bacteremia
ISSN:	0934-9723, 1435-4373, 1435-4373
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Popis
Shrnutí:	Diabetes is associated with an increased susceptibility to infection and sepsis. Conflicting data exist on whether the mortality of patients with sepsis is influenced by the presence of diabetes, fuelling the ongoing debate on the benefit of tight glucose regulation in patients with sepsis. The main reason for which diabetes predisposes to infection appears to be abnormalities of the host response, particularly in neutrophil chemotaxis, adhesion and intracellular killing, defects that have been attributed to the effect of hyperglycaemia. There is also evidence for defects in humoral immunity, and this may play a larger role than previously recognised. We review the literature on the immune response in diabetes and its potential contribution to the pathogenesis of sepsis. In addition, the effect of diabetes treatment on the immune response is discussed, with specific reference to insulin, metformin, sulphonylureas and thiazolidinediones.
Bibliografie:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	0934-9723 1435-4373 1435-4373
DOI:	10.1007/s10096-011-1337-4