Extra View: Sirt1 Acts As A Gatekeeper Of Replication Initiation To Preserve Genomic Stability

Since the discovery of a yeast gene silencing modifier (Silent Information Modifier 2, SIR2) and its role in maintaining genomic stability more than two decades ago, SIR2 homologs (sirtuins) were identified in diverse species. Sirtuins are protein deacetylases that play diverse roles in proper cellu...

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Bibliographic Details
Published in:	Nucleus Vol. 9; no. 1; pp. 307 - 313
Main Authors:	Utani, Koichi, Aladjem, Mirit I.
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 01.01.2018 Informa UK Limited
Subjects:	Animalia Animals Cell cycle cell growth Chromatin Chromosome DNA DNA - genetics DNA repair DNA Replication DNA Replication - genetics Epigenetics Extra View genes Genomic Instability genomics Humans metabolism replication origin Silent Information Regulator Proteins, Saccharomyces cerevisiae Silent Information Regulator Proteins, Saccharomyces cerevisiae - metabolism Sirtuin 1 Sirtuin 1 - metabolism Sirtuin 2 Sirtuin 2 - metabolism sirtuins yeasts Epigenetics Chromosome Chromatin DNA replication Cell cycle
ISSN:	1949-1034, 1949-1042, 1949-1042
Online Access:	Get full text
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