Extra View: Sirt1 Acts As A Gatekeeper Of Replication Initiation To Preserve Genomic Stability

Since the discovery of a yeast gene silencing modifier (Silent Information Modifier 2, SIR2) and its role in maintaining genomic stability more than two decades ago, SIR2 homologs (sirtuins) were identified in diverse species. Sirtuins are protein deacetylases that play diverse roles in proper cellu...

Full description

Saved in:
Bibliographic Details
Published in:Nucleus Vol. 9; no. 1; pp. 307 - 313
Main Authors: Utani, Koichi, Aladjem, Mirit I.
Format: Journal Article
Language:English
Published: United States Taylor & Francis 01.01.2018
Informa UK Limited
Subjects:
Animalia
Animals
Cell cycle
cell growth
Chromatin
Chromosome
DNA
DNA - genetics
DNA repair
DNA Replication
DNA Replication - genetics
Epigenetics
Extra View
genes
Genomic Instability
genomics
Humans
metabolism
replication origin
Silent Information Regulator Proteins, Saccharomyces cerevisiae
Silent Information Regulator Proteins, Saccharomyces cerevisiae - metabolism
Sirtuin 1
Sirtuin 1 - metabolism
Sirtuin 2
Sirtuin 2 - metabolism
sirtuins
yeasts
Epigenetics
Chromosome
Chromatin
DNA replication
Cell cycle
ISSN:1949-1034, 1949-1042, 1949-1042
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract Since the discovery of a yeast gene silencing modifier (Silent Information Modifier 2, SIR2) and its role in maintaining genomic stability more than two decades ago, SIR2 homologs (sirtuins) were identified in diverse species. Sirtuins are protein deacetylases that play diverse roles in proper cellular metabolism including cell cycle progression and maintenance of genomic stability. In yeast, SIR2 interacts with replication origins and protein complexes that affect both replication origin usage and gene silencing. In metazoans, the largest SIR2 homolog, SIRT1, is implicated in epigenetic modifications, circadian signaling, DNA recombination and DNA repair. Until recently, very few studies investigated the role of mammalian SIRT1 in modulating DNA replication. We discuss a newly characterized interaction between human SIRT1 and the DNA replication machinery, reviewing data from recent studies that have investigated how complex signaling pathways that involve SIRT1 affect cellular growth regulatory circuits.
AbstractList Since the discovery of a yeast gene silencing modifier (Silent Information Modifier 2, SIR2) and its role in maintaining genomic stability more than two decades ago, SIR2 homologs (sirtuins) were identified in diverse species. Sirtuins are protein deacetylases that play diverse roles in proper cellular metabolism including cell cycle progression and maintenance of genomic stability. In yeast, SIR2 interacts with replication origins and protein complexes that affect both replication origin usage and gene silencing. In metazoans, the largest SIR2 homolog, SIRT1, is implicated in epigenetic modifications, circadian signaling, DNA recombination and DNA repair. Until recently, very few studies investigated the role of mammalian SIRT1 in modulating DNA replication. We discuss a newly characterized interaction between human SIRT1 and the DNA replication machinery, reviewing data from recent studies that have investigated how complex signaling pathways that involve SIRT1 affect cellular growth regulatory circuits.
Since the discovery of a yeast gene silencing modifier (Silent Information Modifier 2, SIR2) and its role in maintaining genomic stability more than two decades ago, SIR2 homologs (sirtuins) were identified in diverse species. Sirtuins are protein deacetylases that play diverse roles in proper cellular metabolism including cell cycle progression and maintenance of genomic stability. In yeast, SIR2 interacts with replication origins and protein complexes that affect both replication origin usage and gene silencing. In metazoans, the largest SIR2 homolog, SIRT1, is implicated in epigenetic modifications, circadian signaling, DNA recombination and DNA repair. Until recently, very few studies investigated the role of mammalian SIRT1 in modulating DNA replication. We discuss a newly characterized interaction between human SIRT1 and the DNA replication machinery, reviewing data from recent studies that have investigated how complex signaling pathways that involve SIRT1 affect cellular growth regulatory circuits.Since the discovery of a yeast gene silencing modifier (Silent Information Modifier 2, SIR2) and its role in maintaining genomic stability more than two decades ago, SIR2 homologs (sirtuins) were identified in diverse species. Sirtuins are protein deacetylases that play diverse roles in proper cellular metabolism including cell cycle progression and maintenance of genomic stability. In yeast, SIR2 interacts with replication origins and protein complexes that affect both replication origin usage and gene silencing. In metazoans, the largest SIR2 homolog, SIRT1, is implicated in epigenetic modifications, circadian signaling, DNA recombination and DNA repair. Until recently, very few studies investigated the role of mammalian SIRT1 in modulating DNA replication. We discuss a newly characterized interaction between human SIRT1 and the DNA replication machinery, reviewing data from recent studies that have investigated how complex signaling pathways that involve SIRT1 affect cellular growth regulatory circuits.
Author Utani, Koichi
Aladjem, Mirit I.
Author_xml – sequence: 1
  givenname: Koichi
  orcidid: 0000-0002-8065-3161
  surname: Utani
  fullname: Utani, Koichi
  organization: Department of Microbiology, Kanazawa Medical University
– sequence: 2
  givenname: Mirit I.
  surname: Aladjem
  fullname: Aladjem, Mirit I.
  email: aladjemm@mail.nih.gov
  organization: Developmental Therapeutics Branch, Center for Cancer Research, NCI, NIH
BackLink https://cir.nii.ac.jp/crid/1873398392998785024$$DView record in CiNii
https://www.ncbi.nlm.nih.gov/pubmed/29578371$$D View this record in MEDLINE/PubMed
BookMark eNqFUU1vEzEQtVARLaE_AeQDBy4JttfetUGqiKoSKlUqohFHLMeZBcOuHWynbf59nW5SAQdq-WNkvzfzPO85OvDBA0IvKZlQIslbqriipOITRqicUC5qRuUTdLS9H1PC2cFDXPFDdJzST1IG5w0R9Bk6ZEo0smroEfp2dpujwV8d3LzDVy5miqc2JzwtE89Mhl8AK4j4ssVfYNU5a7ILHp97l90QzgP-HCFBvAY8Ax96Z_FVNgvXubx5gZ62pktwvDtHaP7xbH76aXxxOTs_nV6MrVB1HhsuDOeCLY2BZdsuecuNaQWoWlqxEMLWTCm5kKZhCwESJC2xsFIRUkuiqhE6GdKu1oselhZ8-VSnV9H1Jm50ME7__eLdD_09XGuhmoqWNUJvdgli-L2GlHXvkoWuMx7COmkmGGcVKcjHocWSuq6JkgX66k9ZD3r27S-A9wPAxpBShFZbl-_bWlS6TlOit37rvd_3yfXO78IW_7D3BR7jvR543rlScLtTWX5WFKttnxspCOMF9mGAOd-G2JubELulzmbThdhG461Luvp_pTtx2srj
CitedBy_id crossref_primary_10_1016_j_exphem_2023_03_006
crossref_primary_10_1534_genetics_119_302047
crossref_primary_10_3390_ijms25084540
crossref_primary_10_1073_pnas_2004664117
crossref_primary_10_1139_bcb_2019_0054
crossref_primary_10_3390_cells13171469
Cites_doi 10.1126/science.aao3172
10.1093/nar/gkp1039
10.1016/j.cell.2008.07.002
10.1073/pnas.1222494110
10.1038/sj.emboj.7600244
10.1038/nrm3293
10.1016/0092-8674(87)90642-8
10.1074/jbc.M113.520403
10.1172/JCI60818
10.1097/MOH.0000000000000152
10.1242/jcs.001222
10.1371/journal.ppat.1001080
10.1074/jbc.M115.641522
10.1093/nar/gkw322
10.1126/science.1140735
10.1529/biophysj.104.040824
10.1073/pnas.1010377108
10.1073/pnas.1010627107
10.1101/gad.228536.113
10.1038/ncomms8505
10.1038/ncb1848
10.1038/emboj.2011.404
10.1186/2041-9414-4-6
10.1093/nar/gkt131
10.1038/nsmb.2470
10.1016/S0092-8674(01)00524-4
10.1016/j.molcel.2016.09.017
10.1128/MCB.25.8.3109-3116.2005
10.1128/MCB.22.12.4136-4146.2002
10.1016/j.bcp.2014.08.034
10.1128/JVI.00102-17
10.1038/emm.2007.2
10.1371/journal.ppat.1005181
10.1016/j.molcel.2010.07.006
10.1016/j.molcel.2008.02.019
10.1038/nsmb.2543
10.1016/j.cell.2005.01.029
10.1074/mcp.M112.019547
10.1038/ncomms9548
10.7150/ijbs.11066
10.1126/science.1063957
10.1093/nar/gkx468
10.1016/j.molcel.2007.05.029
10.1016/j.molcel.2014.10.007
10.1016/j.molcel.2013.10.029
10.1016/j.ccr.2008.09.001
10.1016/j.cub.2015.09.026
10.1016/S0092-8674(00)80493-6
10.1038/ncomms11748
10.1016/S0092-8674(01)00527-X
10.1016/j.cub.2016.12.047
10.1128/JVI.77.3.2063-2070.2003
10.1016/j.ceb.2016.03.017
10.1074/jbc.M606774200
10.1016/j.cell.2008.10.025
10.1101/gad.9.23.2888
10.1038/nrg.2016.141
10.1038/s41598-017-04847-7
10.1074/jbc.M113.511337
10.1128/JVI.00219-14
10.1038/nrg.2017.46
10.1126/scisignal.aai8026
10.1371/journal.pone.0008414
10.1074/jbc.M709707200
10.1093/nar/gkv1019
10.1016/0092-8674(89)90681-8
ContentType Journal Article
Copyright This work was authored as part of the Contributor's official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law. 2018
This work was authored as part of the Contributor's official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law. 2018 This work was authored as part of the Contributor's official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law.
Copyright_xml – notice: This work was authored as part of the Contributor's official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law. 2018
– notice: This work was authored as part of the Contributor's official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law. 2018 This work was authored as part of the Contributor's official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law.
DBID 0YH
RYH
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
7S9
L.6
5PM
DOI 10.1080/19491034.2018.1456218
DatabaseName Taylor & Francis Open Access
CiNii Complete
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
DatabaseTitleList MEDLINE


AGRICOLA
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 0YH
  name: Taylor & Francis Open Access
  url: https://www.tandfonline.com
  sourceTypes: Publisher
– sequence: 3
  dbid: 7X8
  name: MEDLINE - Academic
  url: https://search.proquest.com/medline
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
DocumentTitleAlternate K. UTANI AND M. I. ALADJEM
EISSN 1949-1042
EndPage 313
ExternalDocumentID PMC5973197
29578371
10_1080_19491034_2018_1456218
1456218
Genre Extra View
Journal Article
Research Support, N.I.H., Intramural
Review
GrantInformation_xml – fundername: National Institutes of Health
  grantid: 1ZIABC010411
– fundername: Intramural NIH HHS
  grantid: ZIA BC010411
– fundername: NCI NIH HHS
  grantid: ZIA BC010411
– fundername: ;
  grantid: 1ZIABC010411
GroupedDBID ---
0YH
4.4
53G
ABCCY
ABDBF
ABPEM
ACGFS
ACUHS
ADBBV
ADCVX
AENEX
AIJEM
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AQTUD
BAWUL
BCNDV
DGEBU
DIK
EBS
EJD
EMOBN
ESX
F5P
GROUPED_DOAJ
GTTXZ
H13
HYE
IPNFZ
M4Z
O9-
OK1
RIG
RPM
SV3
TDBHL
TFL
TFW
TR2
TUS
RYH
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
7S9
L.6
5PM
ID FETCH-LOGICAL-c596t-a45a4452daaedffd4f4aaf5e968c5b55c62998b8a72b5e8e81b8a5c890068093
IEDL.DBID 0YH
ISICitedReferencesCount 10
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000430503300001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 1949-1034
1949-1042
IngestDate Tue Nov 04 02:02:20 EST 2025
Mon May 05 20:51:01 EDT 2025
Thu Jul 10 16:48:14 EDT 2025
Sat May 31 02:09:24 EDT 2025
Sat Nov 29 04:49:38 EST 2025
Tue Nov 18 22:24:30 EST 2025
Mon Nov 10 09:09:22 EST 2025
Mon Oct 20 23:50:08 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords Epigenetics
Chromosome
Chromatin
DNA replication
Cell cycle
Language English
License open-access: http://creativecommons.org/licenses/by/4.0/: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c596t-a45a4452daaedffd4f4aaf5e968c5b55c62998b8a72b5e8e81b8a5c890068093
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ORCID 0000-0002-8065-3161
OpenAccessLink https://www.tandfonline.com/doi/abs/10.1080/19491034.2018.1456218
PMID 29578371
PQID 2018666098
PQPubID 23479
PageCount 7
ParticipantIDs informaworld_taylorfrancis_310_1080_19491034_2018_1456218
proquest_miscellaneous_2524230973
crossref_citationtrail_10_1080_19491034_2018_1456218
proquest_miscellaneous_2018666098
pubmedcentral_primary_oai_pubmedcentral_nih_gov_5973197
pubmed_primary_29578371
crossref_primary_10_1080_19491034_2018_1456218
nii_cinii_1873398392998785024
PublicationCentury 2000
PublicationDate 2018-01-01
PublicationDateYYYYMMDD 2018-01-01
PublicationDate_xml – month: 01
  year: 2018
  text: 2018-01-01
  day: 01
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Nucleus
PublicationTitleAlternate Nucleus
PublicationYear 2018
Publisher Taylor & Francis
Informa UK Limited
Publisher_xml – name: Taylor & Francis
– name: Informa UK Limited
References CIT0030
CIT0032
CIT0031
CIT0034
CIT0033
CIT0036
CIT0035
CIT0038
CIT0037
CIT0039
CIT0041
CIT0040
CIT0043
CIT0042
CIT0001
CIT0045
CIT0044
CIT0003
CIT0047
CIT0002
CIT0046
CIT0005
CIT0049
CIT0004
CIT0048
CIT0007
CIT0006
CIT0009
CIT0008
CIT0050
CIT0052
CIT0051
CIT0010
CIT0054
CIT0053
CIT0012
CIT0056
CIT0011
CIT0055
CIT0014
CIT0058
CIT0013
CIT0057
CIT0016
CIT0015
CIT0059
CIT0018
CIT0017
CIT0019
CIT0061
CIT0060
CIT0063
CIT0062
CIT0021
CIT0065
CIT0020
CIT0064
CIT0023
CIT0022
CIT0066
CIT0025
CIT0024
CIT0027
CIT0026
CIT0029
CIT0028
References_xml – ident: CIT0022
  doi: 10.1126/science.aao3172
– ident: CIT0026
  doi: 10.1093/nar/gkp1039
– ident: CIT0018
  doi: 10.1016/j.cell.2008.07.002
– ident: CIT0020
  doi: 10.1073/pnas.1222494110
– ident: CIT0014
  doi: 10.1038/sj.emboj.7600244
– ident: CIT0004
  doi: 10.1038/nrm3293
– ident: CIT0034
  doi: 10.1016/0092-8674(87)90642-8
– ident: CIT0033
  doi: 10.1074/jbc.M113.520403
– ident: CIT0053
  doi: 10.1172/JCI60818
– ident: CIT0010
  doi: 10.1097/MOH.0000000000000152
– ident: CIT0015
  doi: 10.1242/jcs.001222
– ident: CIT0062
  doi: 10.1371/journal.ppat.1001080
– ident: CIT0063
  doi: 10.1074/jbc.M115.641522
– ident: CIT0035
  doi: 10.1093/nar/gkw322
– ident: CIT0057
  doi: 10.1126/science.1140735
– ident: CIT0017
  doi: 10.1529/biophysj.104.040824
– ident: CIT0028
  doi: 10.1073/pnas.1010377108
– ident: CIT0058
  doi: 10.1073/pnas.1010627107
– ident: CIT0016
  doi: 10.1101/gad.228536.113
– ident: CIT0050
  doi: 10.1038/ncomms8505
– ident: CIT0059
  doi: 10.1038/ncb1848
– ident: CIT0054
  doi: 10.1038/emboj.2011.404
– ident: CIT0019
  doi: 10.1186/2041-9414-4-6
– ident: CIT0040
  doi: 10.1093/nar/gkt131
– ident: CIT0013
  doi: 10.1038/nsmb.2470
– ident: CIT0030
  doi: 10.1016/S0092-8674(01)00524-4
– ident: CIT0044
  doi: 10.1016/j.molcel.2016.09.017
– ident: CIT0021
  doi: 10.1128/MCB.25.8.3109-3116.2005
– ident: CIT0005
  doi: 10.1128/MCB.22.12.4136-4146.2002
– ident: CIT0029
  doi: 10.1016/j.bcp.2014.08.034
– ident: CIT0037
  doi: 10.1128/JVI.00102-17
– ident: CIT0025
  doi: 10.1038/emm.2007.2
– ident: CIT0036
  doi: 10.1371/journal.ppat.1005181
– ident: CIT0027
  doi: 10.1016/j.molcel.2010.07.006
– ident: CIT0003
  doi: 10.1016/j.molcel.2008.02.019
– ident: CIT0055
  doi: 10.1038/nsmb.2543
– ident: CIT0002
  doi: 10.1016/j.cell.2005.01.029
– ident: CIT0012
  doi: 10.1074/mcp.M112.019547
– ident: CIT0046
  doi: 10.1038/ncomms9548
– ident: CIT0041
  doi: 10.7150/ijbs.11066
– ident: CIT0060
  doi: 10.1126/science.1063957
– ident: CIT0048
  doi: 10.1093/nar/gkx468
– ident: CIT0023
  doi: 10.1016/j.molcel.2007.05.029
– ident: CIT0042
  doi: 10.1016/j.molcel.2014.10.007
– ident: CIT0045
  doi: 10.1016/j.molcel.2013.10.029
– ident: CIT0008
  doi: 10.1016/j.ccr.2008.09.001
– ident: CIT0047
  doi: 10.1016/j.cub.2015.09.026
– ident: CIT0007
  doi: 10.1016/S0092-8674(00)80493-6
– ident: CIT0064
  doi: 10.1038/ncomms11748
– ident: CIT0031
  doi: 10.1016/S0092-8674(01)00527-X
– ident: CIT0052
  doi: 10.1016/j.cub.2016.12.047
– ident: CIT0061
  doi: 10.1128/JVI.77.3.2063-2070.2003
– ident: CIT0066
  doi: 10.1016/j.ceb.2016.03.017
– ident: CIT0038
  doi: 10.1074/jbc.M606774200
– ident: CIT0009
  doi: 10.1016/j.cell.2008.10.025
– ident: CIT0001
  doi: 10.1101/gad.9.23.2888
– ident: CIT0043
  doi: 10.1038/nrg.2016.141
– ident: CIT0011
  doi: 10.1038/s41598-017-04847-7
– ident: CIT0049
  doi: 10.1074/jbc.M113.511337
– ident: CIT0039
  doi: 10.1128/JVI.00219-14
– ident: CIT0056
  doi: 10.1038/nrg.2017.46
– ident: CIT0032
  doi: 10.1126/scisignal.aai8026
– ident: CIT0065
  doi: 10.1371/journal.pone.0008414
– ident: CIT0024
  doi: 10.1074/jbc.M709707200
– ident: CIT0051
  doi: 10.1093/nar/gkv1019
– ident: CIT0006
  doi: 10.1016/0092-8674(89)90681-8
SSID ssj0000447051
ssib029915012
ssib038073898
Score 2.1726737
SecondaryResourceType review_article
Snippet Since the discovery of a yeast gene silencing modifier (Silent Information Modifier 2, SIR2) and its role in maintaining genomic stability more than two...
SourceID pubmedcentral
proquest
pubmed
crossref
nii
informaworld
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 307
SubjectTerms Animalia
Animals
Cell cycle
cell growth
Chromatin
Chromosome
DNA
DNA - genetics
DNA repair
DNA Replication
DNA Replication - genetics
Epigenetics
Extra View
genes
Genomic Instability
genomics
Humans
metabolism
replication origin
Silent Information Regulator Proteins, Saccharomyces cerevisiae
Silent Information Regulator Proteins, Saccharomyces cerevisiae - metabolism
Sirtuin 1
Sirtuin 1 - metabolism
Sirtuin 2
Sirtuin 2 - metabolism
sirtuins
yeasts
Title Extra View: Sirt1 Acts As A Gatekeeper Of Replication Initiation To Preserve Genomic Stability
URI https://www.tandfonline.com/doi/abs/10.1080/19491034.2018.1456218
https://cir.nii.ac.jp/crid/1873398392998785024
https://www.ncbi.nlm.nih.gov/pubmed/29578371
https://www.proquest.com/docview/2018666098
https://www.proquest.com/docview/2524230973
https://pubmed.ncbi.nlm.nih.gov/PMC5973197
Volume 9
WOSCitedRecordID wos000430503300001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  customDbUrl:
  eissn: 1949-1042
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000447051
  issn: 1949-1034
  databaseCode: DOA
  dateStart: 20180101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVAWR
  databaseName: Taylor & Francis Journals Complete
  customDbUrl:
  eissn: 1949-1042
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000447051
  issn: 1949-1034
  databaseCode: TFW
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: https://www.tandfonline.com
  providerName: Taylor & Francis
– providerCode: PRVAWR
  databaseName: Taylor & Francis Open Access
  customDbUrl:
  eissn: 1949-1042
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000447051
  issn: 1949-1034
  databaseCode: 0YH
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: https://www.tandfonline.com
  providerName: Taylor & Francis
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELagFKkXHuXRBVoZqdeUOLbXNrcV6lIuBYkVbC-NHMdWI1C22qRA_z0zTrLqopYeQIqsRMk4sT32PPJ5hpB9m_kiDY4nJffjRBSWJwVI8cSILFUeTApn05hsQh0f6_ncfOrRhE0Pq0QbOnSBIuJajZPbFs2AiHsDdjcIOY4eEaZhqoMIZ_ouuZeBaYKorvTkaOVmSYVQaUzCiFQJkg37eG6qaU1CrcUvBflTV9V1uuifkMorMmr68D-07hF50CuodNJx1GNyx9fb5H6XsvLyCTk9_AVvpl8q__Mt_VwtW0Ynrm3oBA6Krrhv3p_7Jf0YKOj2g0eQfkCMUnc6W1DEfSDSkr73cVc0BZU3gnQvn5LZ9HD27ijpczQkTppxm1ghrRAyK631ZQilCMLaIL0ZaycLKd0Y5J0utFVZIb32oCVrK502MemH4c_IRr2o_Q6hLlUly1gQPmPCymBdyUGB8IJZFmRgIyKGYcldH78c02h8z1kf5nTouRx7Lu97bkQOVmTnXQCP2wjM1THP2-g5CV2ak5zfQrsLDAKfhyXTinMTFVCjlZbQmBF5PbBODtMY_83Y2i8umlgLWJKp0X95RqLyi_GVRuR5x26rJmUGll6uoJfUGiOuHsAw4ut36uoshhOXmL3MqBf_0O6XZAsvO9fUK7LRLi_8Ltl0P9qqWe7FGQmlmuu96POAcjb9-htI9DCN
linkProvider Taylor & Francis
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrR1db9Mw0IIBYi_jGzoYGInXsDi2a5u3Cq1sYpQHItgTkePYIgKlU5sN9u-5c5KqRcAeQIqiSPY5ufPZ95HzHSEvbObLNDieVNyPE1FanpQgxRMjslR5MCmcTWOxCTWb6ZMTs34WBsMq0YYOXaKIuFfj4kZn9BAStw-GN0g5ji4RpmGtgwxn-iq5JkHWYlhfPv208rOkQqg0VmFEqATBhoM8fxppQ0RtJDAFAdTU9e-U0V9jKteE1PTW_0DvNtnpVVQ66XjqDrnim7vkRle08uIe-XzwA15NP9b--yv6oV60jE5cu6QTuCg64756f-oX9H2goN0PPkF6hFFK3WM-pxj5gbGW9I2P56IpKL0xTPfiPsmnB_nrw6Sv0pA4acZtYoW0QsisstZXIVQiCGuD9GasnSyldGOQeLrUVmWl9NqDnqytdNrEsh-GPyBbzbzxjwh1qapYxoLwGRNWBusqDiqEF8yyIAMbETHMS-H6DOZYSONbwfpEpwPlCqRc0VNuRF6uwE67FB6XAZj1SS_a6DsJXaGTgl8CuwccAp-Hd6YV5yaqoEYrLQGZEXk-8E4BCxn_ztjGz8-WcRSwJVOj_9JHovqLGZZG5GHHbyuUMgObL1dAJbXBiasOmEh8s6Wpv8SE4hLrlxm1-w94PyM3D_N3x8Xx0eztY7KNTZ2j6gnZahdnfo9cd-dtvVw8jcvzJ3erMcg
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3db9MwED_BYIgXvj_KGBiJ17A4tmubt2pbYQKVSVRjT0SOY4sIlFZtBuy_5-wk1ToN9jCkKIpknxPbZ99Hzr8DeG0yV6TesqRkbpjwwrCkQCmeaJ6l0qFJYU0ak03IyUQdH-vDLppw2YVVBhvat0ARca8Oi3te-j4ibgftbhRyLHhEqMKljiKcqutwI4JjIUtPx19WbpaUc5nGJIyBKglk_Tmev7W0JqHW8EtR_tRVdZEuej6k8oyMGt_9D727B3c6BZWMWo66D9dc_QA225SVpw_h6_5vfDM5qtyvt-RztWgoGdlmSUZ4keCK--7c3C3IJ09Qt-89guQgxCi1j9MZCXEfIdKSvHPxVDRBlTcG6Z4-gul4f7r7PulyNCRW6GGTGC4M5yIrjXGl9yX33BgvnB4qKwoh7BDlnSqUkVkhnHKoJSsjrNIx6Ydmj2GjntXuKRCbypJm1HOXUW6EN7ZkqEA4Tg31wtMB8H5actvhl4c0Gj9y2sGc9iOXh5HLu5EbwJsV2bwF8LiMQJ-d87yJnhPfpjnJ2SW028gg-HnhTpVkTEcFVCupBHZmAK961slxGYd_M6Z2s5NlbAUtyVSrf9QRQfkN-EoDeNKy26pLmcatl0kcJbnGiKsKAUZ8vaSuvkU4cRGyl2n57Ar9fgm3DvfG-ceDyYctuB1KWi_Vc9hoFiduG27an021XLyIi_MPdfowbA
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Extra+View%3A+Sirt1+Acts+As+A+Gatekeeper+Of+Replication+Initiation+To+Preserve+Genomic+Stability&rft.jtitle=Nucleus&rft.au=Koichi+Utani&rft.au=Mirit+I.+Aladjem&rft.date=2018-01-01&rft.pub=Informa+UK+Limited&rft.issn=1949-1034&rft.eissn=1949-1042&rft.volume=9&rft.spage=307&rft.epage=313&rft_id=info:doi/10.1080%2F19491034.2018.1456218
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1949-1034&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1949-1034&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1949-1034&client=summon