Extra View: Sirt1 Acts As A Gatekeeper Of Replication Initiation To Preserve Genomic Stability

Since the discovery of a yeast gene silencing modifier (Silent Information Modifier 2, SIR2) and its role in maintaining genomic stability more than two decades ago, SIR2 homologs (sirtuins) were identified in diverse species. Sirtuins are protein deacetylases that play diverse roles in proper cellu...

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Veröffentlicht in:Nucleus Jg. 9; H. 1; S. 307 - 313
Hauptverfasser: Utani, Koichi, Aladjem, Mirit I.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Taylor & Francis 01.01.2018
Informa UK Limited
Schlagworte:
Animalia
Animals
Cell cycle
cell growth
Chromatin
Chromosome
DNA
DNA - genetics
DNA repair
DNA Replication
DNA Replication - genetics
Epigenetics
Extra View
genes
Genomic Instability
genomics
Humans
metabolism
replication origin
Silent Information Regulator Proteins, Saccharomyces cerevisiae
Silent Information Regulator Proteins, Saccharomyces cerevisiae - metabolism
Sirtuin 1
Sirtuin 1 - metabolism
Sirtuin 2
Sirtuin 2 - metabolism
sirtuins
yeasts
Epigenetics
Chromosome
Chromatin
DNA replication
Cell cycle
ISSN:1949-1034, 1949-1042, 1949-1042
Online-Zugang:Volltext
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Beschreibung
Zusammenfassung:Since the discovery of a yeast gene silencing modifier (Silent Information Modifier 2, SIR2) and its role in maintaining genomic stability more than two decades ago, SIR2 homologs (sirtuins) were identified in diverse species. Sirtuins are protein deacetylases that play diverse roles in proper cellular metabolism including cell cycle progression and maintenance of genomic stability. In yeast, SIR2 interacts with replication origins and protein complexes that affect both replication origin usage and gene silencing. In metazoans, the largest SIR2 homolog, SIRT1, is implicated in epigenetic modifications, circadian signaling, DNA recombination and DNA repair. Until recently, very few studies investigated the role of mammalian SIRT1 in modulating DNA replication. We discuss a newly characterized interaction between human SIRT1 and the DNA replication machinery, reviewing data from recent studies that have investigated how complex signaling pathways that involve SIRT1 affect cellular growth regulatory circuits.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:1949-1034
1949-1042
1949-1042
DOI:10.1080/19491034.2018.1456218