Risk factors for death in 1859 subjects with COVID-19

We studied 1859 subjects with confirmed COVID-19 from seven centers in Wuhan 1651 of whom recovered and 208 died. We interrogated diverse covariates for correlations with risk of death from COVID-19. In multi-variable Cox regression analyses increased hazards of in-hospital death were associated wit...

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Veröffentlicht in:Leukemia Jg. 34; H. 8; S. 2173 - 2183
Hauptverfasser: Chen, Lei, Yu, Jianming, He, Wenjuan, Chen, Li, Yuan, Guolin, Dong, Fang, Chen, Wenlan, Cao, Yulin, Yang, Jingyan, Cai, Liling, Wu, Di, Ran, Qijie, Li, Lei, Liu, Qiaomei, Ren, Wenxiang, Gao, Fei, Wang, Hongxiang, Chen, Zhichao, Gale, Robert Peter, Li, Qiubai, Hu, Yu
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Nature Publishing Group 01.08.2020
Schlagworte:
Adult
Aged
Aged, 80 and over
Betacoronavirus - isolation & purification
Biomarkers - blood
Confidence intervals
Coronavirus Infections - blood
Coronavirus Infections - mortality
Coronavirus Infections - pathology
Coronaviruses
COVID-19
Creatinine
Death
Dimers
Female
Follow-Up Studies
Humans
Lymphocytes
Lymphocytes - pathology
Male
Middle Aged
Mortality
Mortality - trends
Neutrophils - pathology
Pandemics
Platelets
Pneumonia, Viral - blood
Pneumonia, Viral - mortality
Pneumonia, Viral - pathology
Prognosis
Regression analysis
Risk analysis
Risk Factors
ROC Curve
SARS-CoV-2
Severity of Illness Index
Statistical analysis
Survival Rate
Thromboplastin
ISSN:0887-6924, 1476-5551, 1476-5551
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Zusammenfassung:We studied 1859 subjects with confirmed COVID-19 from seven centers in Wuhan 1651 of whom recovered and 208 died. We interrogated diverse covariates for correlations with risk of death from COVID-19. In multi-variable Cox regression analyses increased hazards of in-hospital death were associated with several admission covariates: (1) older age (HR = 1.04; 95% Confidence Interval [CI], 1.03, 1.06 per year increase; P < 0.001); (2) smoking (HR = 1.84 [1.17, 2.92]; P = 0.009); (3) admission temperature per °C increase (HR = 1.32 [1.07, 1.64]; P = 0.009); (4) Log neutrophil-to-lymphocyte ratio (NLR; HR = 3.30 [2.10, 5.19]; P < 0.001); (5) platelets per 10 E + 9/L decrease (HR = 0.996 [0.994, 0.998]; P = 0.001); (6) activated partial thromboplastin (aPTT) per second increase (HR = 1.04 [1.02, 1.05]; P < 0.001); (7) Log D-dimer per mg/l increase (HR = 3.00 [2.17, 4.16]; P < 0.001); and (8) Log serum creatinine per μmol/L increase (HR = 4.55 [2.72, 7.62]; P < 0.001). In piecewise linear regression analyses Log NLR the interval from ≥0.4 to ≤1.0 was significantly associated with an increased risk of death. Our data identify covariates associated with risk of in hospital death in persons with COVID-19.
Bibliographie:ObjectType-Article-1
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ISSN:0887-6924
1476-5551
1476-5551
DOI:10.1038/s41375-020-0911-0