Targeting IL-1β and IL-17A Driven Inflammation during Influenza-Induced Exacerbations of Chronic Lung Inflammation

For patients with chronic lung diseases, such as chronic obstructive pulmonary disease (COPD), exacerbations are life-threatening events causing acute respiratory distress that can even lead to hospitalization and death. Although a great deal of effort has been put into research of exacerbations and...

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Veröffentlicht in:	PloS one Jg. 9; H. 6; S. e98440
Hauptverfasser:	Sichelstiel, Anke, Yadava, Koshika, Trompette, Aurélien, Salami, Olawale, Iwakura, Yoichiro, Nicod, Laurent P., Marsland, Benjamin J.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 11.06.2014 Public Library of Science (PLoS)
Schlagworte:	Animals Antibodies, Neutralizing - immunology Antibodies, Neutralizing - therapeutic use Bacterial infections Biology Biology and Life Sciences Bronchitis Chronic Disease Chronic obstructive pulmonary disease Cytokines Emphysema Humans Infections Inflammation Influenza Influenza, Human - complications Influenza, Human - immunology Influenza, Human - therapy Interleukin Interleukin 1 Interleukin 1 Receptor Antagonist Protein - immunology Interleukin 1 Receptor Antagonist Protein - therapeutic use Interleukin-17 - antagonists & inhibitors Interleukin-17 - immunology Interleukin-1beta - antagonists & inhibitors Interleukin-1beta - immunology Leukocytes (neutrophilic) Lung diseases Medicine Medicine and Health Sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Neutrophil Infiltration Neutrophilia Neutrophils Obstructive lung disease Orthomyxoviridae Infections - complications Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - therapy Pneumonia - complications Pneumonia - immunology Pneumonia - therapy Pulmonary Disease, Chronic Obstructive - complications Pulmonary Disease, Chronic Obstructive - immunology Pulmonary Disease, Chronic Obstructive - therapy Recombinant Proteins - immunology Recombinant Proteins - therapeutic use Recruitment Rodents Therapeutic applications Viral infections Switzerland
ISSN:	1932-6203, 1932-6203
Online-Zugang:	Volltext
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