A mitochondrial root to accelerated ageing and frailty

A discovery metabolomic study was performed in a large cohort of adults to identify circulating biomarkers of frailty. The study found that carnitine and vitamin E pathways were dysregulated in frail compared with non-frail participants. These findings point to dysregulated mitochondrial metabolism...

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Veröffentlicht in:Nature reviews. Endocrinology Jg. 16; H. 3; S. 133 - 134
Hauptverfasser: Ferrucci, Luigi, Zampino, Marta
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Nature Publishing Group 01.03.2020
Schlagworte:
Aging
Biomarkers - metabolism
Carnitine
Carnitine - metabolism
Frailty
Humans
Metabolomics
Mitochondria
Mitochondria - metabolism
Vitamin E
Vitamin E - metabolism
ISSN:1759-5029, 1759-5037, 1759-5037
Online-Zugang:Volltext
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Zusammenfassung:A discovery metabolomic study was performed in a large cohort of adults to identify circulating biomarkers of frailty. The study found that carnitine and vitamin E pathways were dysregulated in frail compared with non-frail participants. These findings point to dysregulated mitochondrial metabolism as a potential root of age-related frailty.
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ISSN:1759-5029
1759-5037
1759-5037
DOI:10.1038/s41574-020-0319-y