Structural prediction of protein models using distance restraints derived from cross-linking mass spectrometry data

This protocol describes a workflow for creating structural models of proteins or protein complexes using distance restraints derived from cross-linking mass spectrometry experiments. The distance restraints are used (i) to adjust preliminary models that are calculated on the basis of a homologous te...

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Bibliographic Details
Published in:	Nature protocols Vol. 13; no. 3; p. 478
Main Authors:	Orbán-Németh, Zsuzsanna, Beveridge, Rebecca, Hollenstein, David M, Rampler, Evelyn, Stranzl, Thomas, Hudecz, Otto, Doblmann, Johannes, Schlögelhofer, Peter, Mechtler, Karl
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01.03.2018
Subjects:	Amino acid sequence Computer applications Computer Simulation Constraints Cross-Linking Reagents - chemistry Crosslinking Data processing Forecasting - methods Homology Mass spectrometry Mass Spectrometry - methods Mass spectroscopy Mathematical models Models, Molecular Predictions Protein Structure, Tertiary - genetics Protein Structure, Tertiary - physiology Proteins Proteins - genetics Proteins - physiology Scientific imaging Source programs Spectroscopy Structural models Workflow
ISSN:	1754-2189, 1750-2799, 1750-2799
Online Access:	Get full text
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