Totipotent Embryonic Stem Cells Arise in Ground-State Culture Conditions

Embryonic stem cells (ESCs) are derived from mammalian embryos during the transition from totipotency, when individual blastomeres can make all lineages, to pluripotency, when they are competent to make only embryonic lineages. ESCs maintained with inhibitors of MEK and GSK3 (2i) are thought to repr...

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Bibliographic Details

Published in:	Cell reports (Cambridge) Vol. 3; no. 6; pp. 1945 - 1957
Main Authors:	Morgani, Sophie M., Canham, Maurice A., Nichols, Jennifer, Sharov, Alexei A., Migueles, Rosa Portero, Ko, Minoru S.H., Brickman, Joshua M.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 27.06.2013 Cell Press Elsevier
Subjects:	Animals Cell Differentiation - physiology Cells, Cultured Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Female Humans Mice Mice, Inbred C57BL Mice, Transgenic Pseudopregnancy Totipotent Stem Cells - cytology Totipotent Stem Cells - metabolism
ISSN:	2211-1247, 2211-1247
Online Access:	Get full text
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