Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment

Aging of the hematopoietic stem cell (HSC) compartment is characterized by lineage bias and reduced stem cell function, the molecular basis of which is largely unknown. Using single-cell transcriptomics, we identified a distinct subpopulation of old HSCs carrying a p53 signature indicative of stem c...

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Veröffentlicht in:	Cell reports (Cambridge) Jg. 19; H. 8; S. 1503 - 1511
Hauptverfasser:	Kirschner, Kristina, Chandra, Tamir, Kiselev, Vladimir, Flores-Santa Cruz, David, Macaulay, Iain C., Park, Hyun Jun, Li, Juan, Kent, David G., Kumar, Rupa, Pask, Dean C., Hamilton, Tina L., Hemberg, Martin, Reik, Wolf, Green, Anthony R.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 23.05.2017 Cell Press Elsevier
Schlagworte:	aging Animals cancer Cell Compartmentation Cell Cycle Cell Proliferation cellular aging Cellular Senescence genomics hematology Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism JAK2 Janus Kinase 2 leukemia Mice Myeloid Cells - metabolism p53 scRNA-seq stem cells Transcription Factors - metabolism stem cells leukemia scRNA-seq hematology cellular aging genomics cancer aging JAK2 p53
ISSN:	2211-1247, 2211-1247
Online-Zugang:	Volltext
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