Time-encoded pseudocontinuous arterial spin labeling: Basic properties and timing strategies for human applications

Purpose In this study, the basic properties and requirements of time‐encoded pseudocontinuous arterial spin labeling (te‐pCASL) are investigated. Also, the extra degree of freedom delivered by changing block durations is explored. Methods First, the minimal duration of encoding blocks, the influence...

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Veröffentlicht in:Magnetic resonance in medicine Jg. 72; H. 6; S. 1712 - 1722
Hauptverfasser: Teeuwisse, Wouter M., Schmid, Sophie, Ghariq, Eidrees, Veer, Ilya M., van Osch, Matthias J.P.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Blackwell Publishing Ltd 01.12.2014
Wiley Subscription Services, Inc
Schlagworte:
Adult
Algorithms
arterial spin labeling
arterial transit time
Blood Flow Velocity - physiology
Coronary Circulation - physiology
Coronary Vessels - anatomy & histology
Coronary Vessels - physiology
Female
Hadamard encoded
Humans
Image Enhancement - methods
Image Interpretation, Computer-Assisted - methods
Imaging, Three-Dimensional - methods
magnetic resonance imaging
Male
Reproducibility of Results
Sensitivity and Specificity
Signal Processing, Computer-Assisted
Spin Labels
time encoded
Hadamard encoded
magnetic resonance imaging
time encoded
arterial spin labeling
arterial transit time
ISSN:0740-3194, 1522-2594, 1522-2594
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Zusammenfassung:Purpose In this study, the basic properties and requirements of time‐encoded pseudocontinuous arterial spin labeling (te‐pCASL) are investigated. Also, the extra degree of freedom delivered by changing block durations is explored. Methods First, the minimal duration of encoding blocks, the influence of cardiac triggering, and the effect of dividing the labeling period into blocks are evaluated. Two new strategies for timing the encoding blocks in te‐pCASL are introduced: variable block duration to compensate for T1‐decay and the free lunch approach that uses the postlabeling delay time that is idle in standard pCASL to acquire arterial transit time (ATT) information. Simulations are used to probe possible signal losses. Results No signal loss was found when dividing the labeling period into blocks with duration >50 ms. In time‐encoded perfusion imaging, no cardiac triggering is required. Summation of results for individual blocks in te‐pCASL postprocessing causes severe loss of temporal SNR. Quality of cerebral blood flow (CBF) maps was not affected by the encoding line order. Conclusion Adjusting the timing of encoding blocks in te‐pCASL allows for tailoring the acquisition to specific applications. With the free lunch setup, te‐pCASL delivers CBF and high resolution ATT maps within a single scan, with a small penalty in tSNR. Magn Reson Med 72:1712–1722, 2014. © 2014 Wiley Periodicals, Inc.
Bibliographie:istex:30B49EC412E73A9D6C0B92089070AF8A4B50C567
ArticleID:MRM25083
ark:/67375/WNG-3S29QPFC-G
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0740-3194
1522-2594
1522-2594
DOI:10.1002/mrm.25083