Autogene cevumeran with or without atezolizumab in advanced solid tumors: a phase 1 trial

Effective targeting of somatic cancer mutations to enhance the efficacy of cancer immunotherapy requires an individualized approach. Autogene cevumeran is a uridine messenger RNA lipoplex-based individualized neoantigen-specific immunotherapy designed from tumor-specific somatic mutation data obtain...

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Bibliographic Details
Published in:	Nature medicine Vol. 31; no. 1; p. 152
Main Authors:	Lopez, Juanita, Powles, Thomas, Braiteh, Fadi, Siu, Lillian L, LoRusso, Patricia, Friedman, Claire F, Balmanoukian, Ani S, Gordon, Michael, Yachnin, Jeffrey, Rottey, Sylvie, Karydis, Ioannis, Fisher, George A, Schmidt, Marcus, Schuler, Martin, Sullivan, Ryan J, Burris, Howard A, Galvao, Vladimir, Henick, Brian S, Dirix, Luc, Jaeger, Dirk, Ott, Patrick A, Wong, Kit Man, Jerusalem, Guy, Schiza, Aglaia, Fong, Lawrence, Steeghs, Neeltje, Leidner, Rom S, Rittmeyer, Achim, Laurie, Scott A, Gort, Eelke, Aljumaily, Raid, Melero, Ignacio, Sabado, Rachel L, Rhee, Ina, Mancuso, Michael R, Muller, Lars, Fine, Gregg D, Yadav, Mahesh, Kim, Leesun, Leveque, Vincent J P, Robert, Alberto, Darwish, Martine, Qi, Ting, Zhu, Jiawen, Zhang, Jingbin, Twomey, Patrick, Rao, Gautham K, Low, Donald W, Petry, Chris, Lo, Amy A, Schartner, Jill M, Delamarre, Lélia, Mellman, Ira, Löwer, Martin, Müller, Felicitas, Derhovanessian, Evelyna, Cortini, Andrea, Manning, Luisa, Maurus, Daniel, Brachtendorf, Sebastian, Lörks, Verena, Omokoko, Tana, Godehardt, Eva, Becker, Dirk, Hawner, Christine, Wallrapp, Christine, Albrecht, Christian, Kröner, Christoph, Tadmor, Arbel D, Diekmann, Jan, Vormehr, Mathias, Jork, Anette, Paruzynski, Anna, Lang, Maren, Blake, Jonathon, Hennig, Oliver, Kuhn, Andreas N, Sahin, Ugur, Türeci, Özlem, Camidge, D Ross
Format:	Journal Article
Language:	English
Published:	United States 01.01.2025
Subjects:	Adult Aged Aged, 80 and over Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - adverse effects Antibodies, Monoclonal, Humanized - therapeutic use Antigens, Neoplasm - immunology Antineoplastic Combined Chemotherapy Protocols - therapeutic use CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology Female Humans Immunotherapy - methods Male Middle Aged Neoplasms - drug therapy Neoplasms - genetics Neoplasms - immunology Neoplasms - pathology Neoplasms - therapy
ISSN:	1546-170X, 1546-170X
Online Access:	Get more information
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