Erythropoietin preserves the endothelial differentiation capacity of cardiac progenitor cells and reduces heart failure during anticancer therapies

Anticancer therapies, such as targeting of STAT3 or the use of anthracyclins (doxorubicin), can induce cardiomyopathy. In mice prone to developing heart failure as a result of reduced cardiac STAT3 expression (cardiomyocyte-restricted deficiency of STAT3) or treatment with doxorubicin, we observed i...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Cell stem cell Ročník 9; číslo 2; s. 131
Hlavní autori:	Hoch, Melanie, Fischer, Philipp, Stapel, Britta, Missol-Kolka, Ewa, Sekkali, Belaid, Scherr, Michaela, Favret, Fabrice, Braun, Thomas, Eder, Matthias, Schuster-Gossler, Karin, Gossler, Achim, Hilfiker, Andres, Balligand, Jean-Luc, Drexler, Helmut, Hilfiker-Kleiner, Denise
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 05.08.2011
Predmet:	Adipocytes - cytology Adipocytes - drug effects Animals Antigens, Ly - metabolism Antineoplastic Agents - adverse effects Capillaries - drug effects Capillaries - pathology Cell Differentiation - drug effects Doxorubicin - pharmacology Doxorubicin - therapeutic use Endothelial Cells - cytology Endothelial Cells - drug effects Endothelial Cells - metabolism Erythropoietin - pharmacology Erythropoietin - therapeutic use Fibroblasts - cytology Fibroblasts - drug effects Gene Deletion Heart Failure - chemically induced Heart Failure - drug therapy Heart Failure - physiopathology Heart Function Tests - drug effects Humans Membrane Proteins - metabolism Mice Mice, Knockout Myocardium - pathology Organ Specificity - drug effects Pericytes - cytology Pericytes - drug effects Receptors, CCR2 - metabolism Receptors, Erythropoietin - metabolism STAT3 Transcription Factor - metabolism Stem Cells - cytology Stem Cells - drug effects Stem Cells - metabolism Survival Analysis Vascular Endothelial Growth Factor Receptor-2 - metabolism
ISSN:	1875-9777, 1875-9777
On-line prístup:	Zistit podrobnosti o prístupe
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Buďte prvý, kto okomentuje tento záznam!