Preventive Therapy for Contacts of Drug-Resistant Tuberculosis

Preventing the progression of a drug-resistant tuberculosis (DR-TB) infection to disease is an important pillar of the DR-TB elimination strategy. International guidelines have recently proposed fluoroquinolones for tuberculosis preventive therapy (TPT) in DR-TB contacts, although the available evid...

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Vydané v:Pathogens (Basel) Ročník 11; číslo 10; s. 1189
Hlavní autori: Kherabi, Yousra, Tunesi, Simone, Kay, Alexander, Guglielmetti, Lorenzo
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland MDPI AG 01.10.2022
MDPI
Predmet:
Bacteriology
Clinical trials
Cohort analysis
contacts
Disease prevention
Disease transmission
Drug resistance
Drug therapy
Fluoroquinolones
Guidelines
Health services
HIV
Households
Human immunodeficiency virus
Infections
Levofloxacin
Life Sciences
Literature reviews
Meta-analysis
Microbiology and Parasitology
multidrug-resistant
Observational studies
Pandemics
Patients
Prevention
Review
State-of-the-art reviews
Therapy
treatment
Tuberculosis
France
Peru
Pakistan
treatment
contacts
prevention
tuberculosis
multidrug-resistant
ISSN:2076-0817, 2076-0817
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Popis
Shrnutí:Preventing the progression of a drug-resistant tuberculosis (DR-TB) infection to disease is an important pillar of the DR-TB elimination strategy. International guidelines have recently proposed fluoroquinolones for tuberculosis preventive therapy (TPT) in DR-TB contacts, although the available evidence is low quality. The pooled data from small observational studies suggest that a fluoroquinolone-based TPT is safe, effective and cost-effective as a preventive treatment in DR-TB contacts. Three clinical trials are currently ongoing to generate higher quality evidence on the efficacy of levofloxacin and delamanid as a DR-TB preventive therapy. Additional evidence is also needed, regarding TPT treatment in fluoroquinolone-resistant-TB contacts, patient and health care worker perceptions on DR-TB preventive therapy for contacts, and the service delivery models to increase DR-TPT access. This state-of-the-art review presents the current literature on TPT for contacts of DR-TB cases, focusing on the available evidence and international guidelines.
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ISSN:2076-0817
2076-0817
DOI:10.3390/pathogens11101189