Coagulation Status and Venous Thromboembolism Risk in African Americans: A Potential Risk Factor in COVID-19

Severe acute respiratory syndrome coronavirus 2 infection (COVID-19) is known to induce severe inflammation and activation of the coagulation system, resulting in a prothrombotic state. Although inflammatory conditions and organ-specific diseases have been shown to be strong determinants of morbidit...

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Vydáno v:	Clinical and applied thrombosis/hemostasis Ročník 26; s. 1076029620943671
Hlavní autoři:	Frydman, Galit H., Boyer, Edward W., Nazarian, Rosalynn M., Van Cott, Elizabeth M., Piazza, Gregory
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Los Angeles, CA SAGE Publications 2020 SAGE PUBLICATIONS, INC SAGE Publishing
Témata:	African Americans African Americans - genetics Anemia, Sickle Cell - blood Anemia, Sickle Cell - ethnology Anticoagulants - therapeutic use Betacoronavirus Blood Proteins - analysis Blood Proteins - genetics Clinical Trials as Topic Comorbidity Coronavirus Infections - blood Coronavirus Infections - complications Coronavirus Infections - ethnology Coronaviruses COVID-19 Factor VIII - analysis Female Fibrin Fibrinogen Degradation Products - analysis Genetic Association Studies Genetic Predisposition to Disease Healthcare Disparities Humans Lupus Erythematosus, Systemic - blood Lupus Erythematosus, Systemic - ethnology Male Mortality Pandemics Patient Selection Pneumonia, Viral - blood Pneumonia, Viral - complications Pneumonia, Viral - ethnology Polymorphism, Single Nucleotide Prevalence Renal Insufficiency, Chronic - blood Renal Insufficiency, Chronic - ethnology Review Risk Factors SARS-CoV-2 Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Social Determinants of Health Socioeconomic Factors Thrombophilia - blood Thrombophilia - drug therapy Thrombophilia - ethnology Thrombophilia - etiology Venous Thromboembolism - blood Venous Thromboembolism - ethnology Venous Thromboembolism - etiology Venous Thromboembolism - prevention & control COVID-19 SARS-CoV-2 thrombosis race ethnicity anticoagulation coagulation
ISSN:	1076-0296, 1938-2723, 1938-2723
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Shrnutí:	Severe acute respiratory syndrome coronavirus 2 infection (COVID-19) is known to induce severe inflammation and activation of the coagulation system, resulting in a prothrombotic state. Although inflammatory conditions and organ-specific diseases have been shown to be strong determinants of morbidity and mortality in patients with COVID-19, it is unclear whether preexisting differences in coagulation impact the severity of COVID-19. African Americans have higher rates of COVID-19 infection and disease-related morbidity and mortality. Moreover, African Americans are known to be at a higher risk for thrombotic events due to both biological and socioeconomic factors. In this review, we explore whether differences in baseline coagulation status and medical management of coagulation play an important role in COVID-19 disease severity and contribute to racial disparity trends within COVID-19.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	1076-0296 1938-2723 1938-2723
DOI:	10.1177/1076029620943671