Coagulation Status and Venous Thromboembolism Risk in African Americans: A Potential Risk Factor in COVID-19

Severe acute respiratory syndrome coronavirus 2 infection (COVID-19) is known to induce severe inflammation and activation of the coagulation system, resulting in a prothrombotic state. Although inflammatory conditions and organ-specific diseases have been shown to be strong determinants of morbidit...

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Bibliographic Details
Published in:Clinical and applied thrombosis/hemostasis Vol. 26; p. 1076029620943671
Main Authors: Frydman, Galit H., Boyer, Edward W., Nazarian, Rosalynn M., Van Cott, Elizabeth M., Piazza, Gregory
Format: Journal Article
Language:English
Published: Los Angeles, CA SAGE Publications 2020
SAGE PUBLICATIONS, INC
SAGE Publishing
Subjects:
African Americans
African Americans - genetics
Anemia, Sickle Cell - blood
Anemia, Sickle Cell - ethnology
Anticoagulants - therapeutic use
Betacoronavirus
Blood Proteins - analysis
Blood Proteins - genetics
Clinical Trials as Topic
Comorbidity
Coronavirus Infections - blood
Coronavirus Infections - complications
Coronavirus Infections - ethnology
Coronaviruses
COVID-19
Factor VIII - analysis
Female
Fibrin Fibrinogen Degradation Products - analysis
Genetic Association Studies
Genetic Predisposition to Disease
Healthcare Disparities
Humans
Lupus Erythematosus, Systemic - blood
Lupus Erythematosus, Systemic - ethnology
Male
Mortality
Pandemics
Patient Selection
Pneumonia, Viral - blood
Pneumonia, Viral - complications
Pneumonia, Viral - ethnology
Polymorphism, Single Nucleotide
Prevalence
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - ethnology
Review
Risk Factors
SARS-CoV-2
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Social Determinants of Health
Socioeconomic Factors
Thrombophilia - blood
Thrombophilia - drug therapy
Thrombophilia - ethnology
Thrombophilia - etiology
Venous Thromboembolism - blood
Venous Thromboembolism - ethnology
Venous Thromboembolism - etiology
Venous Thromboembolism - prevention & control
COVID-19
SARS-CoV-2
thrombosis
race
ethnicity
anticoagulation
coagulation
ISSN:1076-0296, 1938-2723, 1938-2723
Online Access:Get full text
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Summary:Severe acute respiratory syndrome coronavirus 2 infection (COVID-19) is known to induce severe inflammation and activation of the coagulation system, resulting in a prothrombotic state. Although inflammatory conditions and organ-specific diseases have been shown to be strong determinants of morbidity and mortality in patients with COVID-19, it is unclear whether preexisting differences in coagulation impact the severity of COVID-19. African Americans have higher rates of COVID-19 infection and disease-related morbidity and mortality. Moreover, African Americans are known to be at a higher risk for thrombotic events due to both biological and socioeconomic factors. In this review, we explore whether differences in baseline coagulation status and medical management of coagulation play an important role in COVID-19 disease severity and contribute to racial disparity trends within COVID-19.
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ISSN:1076-0296
1938-2723
1938-2723
DOI:10.1177/1076029620943671