Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies

Genome-wide association studies (GWAS) in Parkinson's disease have increased the scope of biological knowledge about the disease over the past decade. We aimed to use the largest aggregate of GWAS data to identify novel risk loci and gain further insight into the causes of Parkinson's dise...

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Bibliographic Details
Published in:	Lancet neurology Vol. 18; no. 12; pp. 1091 - 1102
Main Authors:	Vallerga, Costanza L, Tan, Manuela, Kia, Demis A, Xue, Angli, Young, Emily, Sharma, Manu, Krohn, Lynne, Siitonen, Ari, Iwaki, Hirotaka, Leonard, Hampton, Botia, Juan A, Martinez, Maria, Jankovic, Joseph, Sutherland, Margaret, Majamaa, Kari, Andreassen, Ole A, Gan-Or, Ziv, Gasser, Thomas, Heutink, Peter, Gratten, Jacob, Alvarez, Ignacio, Alvarez, Victoria, Bandres-Ciga, Sara, Bergareche Yarza, Jesús Alberto, Billingsley, Kimberley, Bonilla-Toribio, Marta, Botía, Juan A, Boungiorno, María Teresa, Bras, Jose, Bubb, Vivien, Buiza-Rueda, Dolores, Cerdan, Debora, Chelban, Viorica, Corvol, Jean-Christophe, Craig, David W, Danjou, Fabrice, Diez-Fairen, Monica, Escott-Price, Valentina, Ezquerra, Mario, Fernández, Manel, Fernández-Santiago, Rubén, Garcia, Ciara, García-Ruiz, Pedro, Hernandez, Dena G, Hoenicka, Janet, Infante, Jon, Jesús, Silvia, Kaiyrzhanov, Rauan, Leonard, Hampton L, Lewis, Patrick, Lopez-Sendon, Jose Luis, Lovering, Ruth, Lubbe, Steven, Manzoni, Claudia, Marti, Maria Jose, Méndez-del-Barrio, Carlota, Middlehurst, Ben, Mínguez, Adolfo, Muñoz, Esteban, Pagola, Ana Gorostidi, Pastor, Pau, Perez Errazquin, Francisco, Periñán-Tocino, Teresa, Reed, Xylena, Rezola, Elisabet Mondragon, Rodriguez, Antonio Sanchez, Ruiz-Martínez, Javier, Sadykova, Dinara, Shashkin, Chingiz, Sierra, María, Simón-Sánchez, Javier, Singleton, Andrew B, Suarez-Sanmartin, Esther, Tabernero, Cesar, Tolosa, Eduard, van Hilten, Jacobus J, Vargas-González, Laura, Wood, Nicholas W, Zimprich, Alexander, Reich, Stephen, Savitt, Joseph, Bryc, Katarzyna, Hicks, Barry, Jiang, Yunxuan, McCreight, Jennifer C., McIntyre, Matthew H., Noblin, Elizabeth S., Sathirapongsasuti, J. Fah, Tung, Joyce, Anderson, Tim, Bentley, Steven, Kennedy, Martin, Mellick, George, Sidorenko, Julia, Silburn, Peter A., Visscher, Peter M., Yang, Jian
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.12.2019 Elsevier Limited Elsevier
Subjects:	Aging Clinical trials Cognitive ability Databases, Genetic Datasets DNA methylation Gene expression Genetic Loci - genetics Genetic Predisposition to Disease - epidemiology Genetic Predisposition to Disease - genetics Genome-Wide Association Study - methods Genomes Genomics Heritability Human health and pathology Humans Life Sciences Meta-analysis Movement disorders Neurodegenerative diseases Parkinson Disease - diagnosis Parkinson Disease - epidemiology Parkinson Disease - genetics Parkinson's disease Phenotypes Prediction models Putamen Risk Factors Single-nucleotide polymorphism Systematic review
ISSN:	1474-4422, 1474-4465, 1474-4465
Online Access:	Get full text
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