Using multiple genetic variants as instrumental variables for modifiable risk factors

Mendelian randomisation analyses use genetic variants as instrumental variables (IVs) to estimate causal effects of modifiable risk factors on disease outcomes. Genetic variants typically explain a small proportion of the variability in risk factors; hence Mendelian randomisation analyses can requir...

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Veröffentlicht in:	Statistical methods in medical research Jg. 21; H. 3; S. 223 - 242
Hauptverfasser:	Palmer, Tom M, Lawlor, Debbie A, Harbord, Roger M, Sheehan, Nuala A, Tobias, Jon H, Timpson, Nicholas J, Smith, George Davey, Sterne, Jonathan AC
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London, England SAGE Publications 01.06.2012 Sage Publications Ltd
Schlagworte:	Alleles Analysis Bias Body fat Bone density Bone mineral density Causality Children Cohort analysis Data processing Disease Female Genetic Variation Genetics Genomics Genotype Humans Male Mendelian Randomization Analysis Missing data Multiple imputation Property Risk Factors Simulation Statistics Variability Variables Variants Violations epidemiology econometrics genetics instrumental variables causal inference Mendelian randomisation
ISSN:	0962-2802, 1477-0334, 1477-0334
Online-Zugang:	Volltext
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