Using multiple genetic variants as instrumental variables for modifiable risk factors

Mendelian randomisation analyses use genetic variants as instrumental variables (IVs) to estimate causal effects of modifiable risk factors on disease outcomes. Genetic variants typically explain a small proportion of the variability in risk factors; hence Mendelian randomisation analyses can requir...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Statistical methods in medical research Ročník 21; číslo 3; s. 223 - 242
Hlavní autori:	Palmer, Tom M, Lawlor, Debbie A, Harbord, Roger M, Sheehan, Nuala A, Tobias, Jon H, Timpson, Nicholas J, Smith, George Davey, Sterne, Jonathan AC
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London, England SAGE Publications 01.06.2012 Sage Publications Ltd
Predmet:	Alleles Analysis Bias Body fat Bone density Bone mineral density Causality Children Cohort analysis Data processing Disease Female Genetic Variation Genetics Genomics Genotype Humans Male Mendelian Randomization Analysis Missing data Multiple imputation Property Risk Factors Simulation Statistics Variability Variables Variants Violations epidemiology econometrics genetics instrumental variables causal inference Mendelian randomisation
ISSN:	0962-2802, 1477-0334, 1477-0334
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Buďte prvý, kto okomentuje tento záznam!