Using multiple genetic variants as instrumental variables for modifiable risk factors

Mendelian randomisation analyses use genetic variants as instrumental variables (IVs) to estimate causal effects of modifiable risk factors on disease outcomes. Genetic variants typically explain a small proportion of the variability in risk factors; hence Mendelian randomisation analyses can requir...

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Bibliographic Details
Published in:	Statistical methods in medical research Vol. 21; no. 3; pp. 223 - 242
Main Authors:	Palmer, Tom M, Lawlor, Debbie A, Harbord, Roger M, Sheehan, Nuala A, Tobias, Jon H, Timpson, Nicholas J, Smith, George Davey, Sterne, Jonathan AC
Format:	Journal Article
Language:	English
Published:	London, England SAGE Publications 01.06.2012 Sage Publications Ltd
Subjects:	Alleles Analysis Bias Body fat Bone density Bone mineral density Causality Children Cohort analysis Data processing Disease Female Genetic Variation Genetics Genomics Genotype Humans Male Mendelian Randomization Analysis Missing data Multiple imputation Property Risk Factors Simulation Statistics Variability Variables Variants Violations epidemiology econometrics genetics instrumental variables causal inference Mendelian randomisation
ISSN:	0962-2802, 1477-0334, 1477-0334
Online Access:	Get full text
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