Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells

Cysteinyl leukotrienes (cysLT), i.e., LTC4, LTD4, and LTE4, are lipid mediators derived from the 5-lipoxygenase pathway, and the cysLT receptors cysLT1-R/cysLT2-R mediate inflammatory tissue reactions. Although endothelial cells (ECs) predominantly express cysLT2-Rs, their role in vascular biology r...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 103; H. 16; S. 6326
Hauptverfasser:	Uzonyi, Barbara, Lötzer, Katharina, Jahn, Steffen, Kramer, Cornelia, Hildner, Markus, Bretschneider, Ellen, Radke, Dörte, Beer, Michael, Vollandt, Rüdiger, Evans, Jilly F, Funk, Colin D, Habenicht, Andreas J R
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 18.04.2006
Schlagworte:	Blood Coagulation - drug effects Blood Coagulation - physiology Cells, Cultured Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Gene Expression Regulation Humans Leukotriene C4 - metabolism Leukotriene C4 - pharmacology Membrane Proteins - agonists Membrane Proteins - physiology Receptor, PAR-1 - agonists Receptor, PAR-1 - physiology Receptors, Cytoplasmic and Nuclear Receptors, Leukotriene - agonists Receptors, Leukotriene - physiology Thrombin - metabolism Thrombin - pharmacology Transcription, Genetic - drug effects Umbilical Veins - cytology
ISSN:	0027-8424
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