Presence of antibody-dependent cellular cytotoxicity (ADCC) against SARS-CoV-2 in COVID-19 plasma

Neutralizing-antibody (nAb) is the major focus of most ongoing COVID-19 vaccine trials. However, nAb response against SARS-CoV-2, when present, decays rapidly. Given the myriad roles of antibodies in immune responses, it is possible that antibodies could also mediate protection against SARS-CoV-2 vi...

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Bibliographic Details
Published in:	PloS one Vol. 16; no. 3; p. e0247640
Main Authors:	Tso, For Yue, Lidenge, Salum J., Poppe, Lisa K., Peña, Phoebe B., Privatt, Sara R., Bennett, Sydney J., Ngowi, John R., Mwaiselage, Julius, Belshan, Michael, Siedlik, Jacob A., Raine, Morgan A., Ochoa, Juan B., Garcia-Diaz, Julia, Nossaman, Bobby, Buckner, Lyndsey, Roberts, W. Mark, Dean, Matthew J., Ochoa, Augusto C., West, John T., Wood, Charles
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 04.03.2021 Public Library of Science (PLoS)
Subjects:	2-Mercaptoethanol Adult Aged Aged, 80 and over Amino acids Antibodies Antibodies, Neutralizing - blood Antibodies, Neutralizing - immunology Antibodies, Viral - blood Antibodies, Viral - immunology Antibody-Dependent Cell Cytotoxicity Biochemistry Biology and life sciences Blood plasma Cancer CD16 antigen Coronaviruses COVID-19 COVID-19 - blood COVID-19 - immunology Cytotoxicity Degranulation Editing Effector cells Epidemics Female Folic acid Genetic aspects Glutamine Health aspects Health care facilities HEK293 Cells Humans Immunoglobulin G - blood Immunoglobulin G - immunology Immunology Inositol Internal medicine Male Medicine Medicine and health sciences Microbiology Middle Aged Natural killer cells Oceans Opsonization Pandemics Pediatrics Perforin Physiological aspects Plasma Prevention Pyruvic acid Research and Analysis Methods Roads SARS-CoV-2 - immunology Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Sodium Sodium bicarbonate Sodium pyruvate Spike Glycoprotein, Coronavirus - immunology Surgery Toxicity United States Vaccines Viral diseases Virology Viruses Visualization Young Adult United States Louisiana United States > US Tanzania Nebraska
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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