Cloning of HSP90, expression and localization of HSP70/90 in different tissues including lactating/non-lactating yak (Bos grunniens) breast tissue
The aim of this study is to investigate the expression and localization of HSP70/90 in different tissues and explore the regulation effects of HSP70/90 at lactation period of female yaks. HSP90 mRNA was cloned from the heart samples of female yaks, Quantitative real-time (qRT-PCR), Western blotting...
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| Vydáno v: | PloS one Ročník 12; číslo 7; s. e0179321 |
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17.07.2017
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| Abstract | The aim of this study is to investigate the expression and localization of HSP70/90 in different tissues and explore the regulation effects of HSP70/90 at lactation period of female yaks. HSP90 mRNA was cloned from the heart samples of female yaks, Quantitative real-time (qRT-PCR), Western blotting (WB), immunohistochemistry and immunofluorescence assays were utilized to analyze the expressions of HSP70/90 mRNA and protein in different tissues. Sequence analysis showed that HSP90 is a conserved molecular chaperone of female yaks. The qRT-PCR, WB results showed that the expressions of HSP70/90 mRNA and protein were significantly different in different tissues, and 3-fold higher expression during the lactation period than the non-lactation period of breast tissue (P < 0.01). Immunohistochemistry and immunofluorescence assays results showed that HSP70/90 were located in the cardiac muscle cells, cerebellar medulla, theca cells lining at the reproductive system, and the mammary epithelia of the breasts. In addition, the expression level of HSP70 was higher than those of HSP90 in all examined tissues. Therefore, our results strongly suggest that the expression and localization of HSP70/90 could provide significant evidence to further research in tissue specific expression, and lactation function of female yaks. |
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| AbstractList | The aim of this study is to investigate the expression and localization of HSP70/90 in different tissues and explore the regulation effects of HSP70/90 at lactation period of female yaks. HSP90 mRNA was cloned from the heart samples of female yaks, Quantitative real-time (qRT-PCR), Western blotting (WB), immunohistochemistry and immunofluorescence assays were utilized to analyze the expressions of HSP70/90 mRNA and protein in different tissues. Sequence analysis showed that HSP90 is a conserved molecular chaperone of female yaks. The qRT-PCR, WB results showed that the expressions of HSP70/90 mRNA and protein were significantly different in different tissues, and 3-fold higher expression during the lactation period than the non-lactation period of breast tissue (P < 0.01). Immunohistochemistry and immunofluorescence assays results showed that HSP70/90 were located in the cardiac muscle cells, cerebellar medulla, theca cells lining at the reproductive system, and the mammary epithelia of the breasts. In addition, the expression level of HSP70 was higher than those of HSP90 in all examined tissues. Therefore, our results strongly suggest that the expression and localization of HSP70/90 could provide significant evidence to further research in tissue specific expression, and lactation function of female yaks.The aim of this study is to investigate the expression and localization of HSP70/90 in different tissues and explore the regulation effects of HSP70/90 at lactation period of female yaks. HSP90 mRNA was cloned from the heart samples of female yaks, Quantitative real-time (qRT-PCR), Western blotting (WB), immunohistochemistry and immunofluorescence assays were utilized to analyze the expressions of HSP70/90 mRNA and protein in different tissues. Sequence analysis showed that HSP90 is a conserved molecular chaperone of female yaks. The qRT-PCR, WB results showed that the expressions of HSP70/90 mRNA and protein were significantly different in different tissues, and 3-fold higher expression during the lactation period than the non-lactation period of breast tissue (P < 0.01). Immunohistochemistry and immunofluorescence assays results showed that HSP70/90 were located in the cardiac muscle cells, cerebellar medulla, theca cells lining at the reproductive system, and the mammary epithelia of the breasts. In addition, the expression level of HSP70 was higher than those of HSP90 in all examined tissues. Therefore, our results strongly suggest that the expression and localization of HSP70/90 could provide significant evidence to further research in tissue specific expression, and lactation function of female yaks. The aim of this study is to investigate the expression and localization of HSP70/90 in different tissues and explore the regulation effects of HSP70/90 at lactation period of female yaks. HSP90 mRNA was cloned from the heart samples of female yaks, Quantitative real-time (qRT-PCR), Western blotting (WB), immunohistochemistry and immunofluorescence assays were utilized to analyze the expressions of HSP70/90 mRNA and protein in different tissues. Sequence analysis showed that HSP90 is a conserved molecular chaperone of female yaks. The qRT-PCR, WB results showed that the expressions of HSP70/90 mRNA and protein were significantly different in different tissues, and 3-fold higher expression during the lactation period than the non-lactation period of breast tissue (P < 0.01). Immunohistochemistry and immunofluorescence assays results showed that HSP70/90 were located in the cardiac muscle cells, cerebellar medulla, theca cells lining at the reproductive system, and the mammary epithelia of the breasts. In addition, the expression level of HSP70 was higher than those of HSP90 in all examined tissues. Therefore, our results strongly suggest that the expression and localization of HSP70/90 could provide significant evidence to further research in tissue specific expression, and lactation function of female yaks. |
| Audience | Academic |
| Author | Pan, Yangyang Yu, Sijiu Liu, Penggang Yang, Kun Wen, Zexing Yang, Xue Cui, Yan He, Junfeng Song, Liangli Yu, Chuan |
| AuthorAffiliation | College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, Gansu, China Technische Universitat Munchen, GERMANY |
| AuthorAffiliation_xml | – name: College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, Gansu, China – name: Technische Universitat Munchen, GERMANY |
| Author_xml | – sequence: 1 givenname: Penggang surname: Liu fullname: Liu, Penggang – sequence: 2 givenname: Sijiu surname: Yu fullname: Yu, Sijiu – sequence: 3 givenname: Yan orcidid: 0000-0002-4699-5942 surname: Cui fullname: Cui, Yan – sequence: 4 givenname: Junfeng surname: He fullname: He, Junfeng – sequence: 5 givenname: Chuan surname: Yu fullname: Yu, Chuan – sequence: 6 givenname: Zexing surname: Wen fullname: Wen, Zexing – sequence: 7 givenname: Yangyang surname: Pan fullname: Pan, Yangyang – sequence: 8 givenname: Kun surname: Yang fullname: Yang, Kun – sequence: 9 givenname: Liangli surname: Song fullname: Song, Liangli – sequence: 10 givenname: Xue surname: Yang fullname: Yang, Xue |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28715410$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1093_aesa_saac015 crossref_primary_10_3390_metabo12111114 crossref_primary_10_1080_09291016_2018_1424770 crossref_primary_10_1016_j_theriogenology_2019_02_039 crossref_primary_10_1007_s00484_018_1549_8 crossref_primary_10_1002_jcp_26822 crossref_primary_10_1007_s10735_021_10054_6 |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interests exist. Conceptualization: YC.Data curation: PL YC.Formal analysis: PL YC.Funding acquisition: YC.Investigation: PL SY JH CY ZW YP KY LS XY.Methodology: PL CY LS.Project administration: YC.Resources: PL YC.Software: PL.Supervision: YC.Validation: PL SY JH CY ZW YP KY LS XY.Visualization: PL YC XY.Writing – original draft: PL.Writing – review & editing: PL YC. |
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| Title | Cloning of HSP90, expression and localization of HSP70/90 in different tissues including lactating/non-lactating yak (Bos grunniens) breast tissue |
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