Aortic pulse wave velocity predicts cardiovascular mortality in middle-aged and elderly Japanese men

Aortic pulse wave velocity (PWV) is widely used as a noninvasive index of arterial stiffness and was used in the present study to investigate the relationship between PWV and cardiovascular mortality in the middle-aged and elderly Japanese population using a longitudinal study design. From 1988 to 2...

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Veröffentlicht in:Circulation journal : official journal of the Japanese Circulation Society Jg. 73; H. 3; S. 549
Hauptverfasser: Inoue, Noriko, Maeda, Ryo, Kawakami, Hideshi, Shokawa, Tomoki, Yamamoto, Hideya, Ito, Chikako, Sasaki, Hideo
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Japan 2009
Schlagworte:
Age Distribution
Aged
Aorta - physiology
Arteriosclerosis - ethnology
Arteriosclerosis - mortality
Arteriosclerosis - physiopathology
Asian Continental Ancestry Group
Blood Flow Velocity - physiology
Blood Pressure
Follow-Up Studies
Humans
Male
Middle Aged
Predictive Value of Tests
Pulsatile Flow - physiology
Risk Factors
Survival Analysis
ISSN:1346-9843
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Abstract Aortic pulse wave velocity (PWV) is widely used as a noninvasive index of arterial stiffness and was used in the present study to investigate the relationship between PWV and cardiovascular mortality in the middle-aged and elderly Japanese population using a longitudinal study design. From 1988 to 2003, a total of 3,960 men (50-69 years old at baseline) who underwent medical check-ups and measurement of PWV, which was standardized for diastolic blood pressure, were recruited and divided into 4 groups according to the PWV values. The average follow-up period was 8.2 years. Mortality from all-causes and from cardiovascular disease significantly increased as PWV increased in the entire follow-up period. Multivariate-adjusted relative risks of all-cause and cardiovascular disease mortality for the highest quartile of PWV (>9.0 m/s) were 1.28 (95% confidence interval (CI) 0.97-1.68) and 1.83 (95%CI 1.02-3.29), respectively, compared with the lowest quartile (<7.5 m/s). An increased PWV can predict cardiovascular mortality in middle-aged and elderly Japanese men.
AbstractList Aortic pulse wave velocity (PWV) is widely used as a noninvasive index of arterial stiffness and was used in the present study to investigate the relationship between PWV and cardiovascular mortality in the middle-aged and elderly Japanese population using a longitudinal study design. From 1988 to 2003, a total of 3,960 men (50-69 years old at baseline) who underwent medical check-ups and measurement of PWV, which was standardized for diastolic blood pressure, were recruited and divided into 4 groups according to the PWV values. The average follow-up period was 8.2 years. Mortality from all-causes and from cardiovascular disease significantly increased as PWV increased in the entire follow-up period. Multivariate-adjusted relative risks of all-cause and cardiovascular disease mortality for the highest quartile of PWV (>9.0 m/s) were 1.28 (95% confidence interval (CI) 0.97-1.68) and 1.83 (95%CI 1.02-3.29), respectively, compared with the lowest quartile (<7.5 m/s). An increased PWV can predict cardiovascular mortality in middle-aged and elderly Japanese men.
Aortic pulse wave velocity (PWV) is widely used as a noninvasive index of arterial stiffness and was used in the present study to investigate the relationship between PWV and cardiovascular mortality in the middle-aged and elderly Japanese population using a longitudinal study design.BACKGROUNDAortic pulse wave velocity (PWV) is widely used as a noninvasive index of arterial stiffness and was used in the present study to investigate the relationship between PWV and cardiovascular mortality in the middle-aged and elderly Japanese population using a longitudinal study design.From 1988 to 2003, a total of 3,960 men (50-69 years old at baseline) who underwent medical check-ups and measurement of PWV, which was standardized for diastolic blood pressure, were recruited and divided into 4 groups according to the PWV values. The average follow-up period was 8.2 years. Mortality from all-causes and from cardiovascular disease significantly increased as PWV increased in the entire follow-up period. Multivariate-adjusted relative risks of all-cause and cardiovascular disease mortality for the highest quartile of PWV (>9.0 m/s) were 1.28 (95% confidence interval (CI) 0.97-1.68) and 1.83 (95%CI 1.02-3.29), respectively, compared with the lowest quartile (<7.5 m/s).METHODS AND RESULTSFrom 1988 to 2003, a total of 3,960 men (50-69 years old at baseline) who underwent medical check-ups and measurement of PWV, which was standardized for diastolic blood pressure, were recruited and divided into 4 groups according to the PWV values. The average follow-up period was 8.2 years. Mortality from all-causes and from cardiovascular disease significantly increased as PWV increased in the entire follow-up period. Multivariate-adjusted relative risks of all-cause and cardiovascular disease mortality for the highest quartile of PWV (>9.0 m/s) were 1.28 (95% confidence interval (CI) 0.97-1.68) and 1.83 (95%CI 1.02-3.29), respectively, compared with the lowest quartile (<7.5 m/s).An increased PWV can predict cardiovascular mortality in middle-aged and elderly Japanese men.CONCLUSIONSAn increased PWV can predict cardiovascular mortality in middle-aged and elderly Japanese men.
Author Shokawa, Tomoki
Kawakami, Hideshi
Inoue, Noriko
Maeda, Ryo
Sasaki, Hideo
Yamamoto, Hideya
Ito, Chikako
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  surname: Inoue
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  surname: Maeda
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  surname: Shokawa
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  givenname: Hideya
  surname: Yamamoto
  fullname: Yamamoto, Hideya
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  givenname: Chikako
  surname: Ito
  fullname: Ito, Chikako
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  surname: Sasaki
  fullname: Sasaki, Hideo
BackLink https://www.ncbi.nlm.nih.gov/pubmed/19179770$$D View this record in MEDLINE/PubMed
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Snippet Aortic pulse wave velocity (PWV) is widely used as a noninvasive index of arterial stiffness and was used in the present study to investigate the relationship...
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SubjectTerms Age Distribution
Aged
Aorta - physiology
Arteriosclerosis - ethnology
Arteriosclerosis - mortality
Arteriosclerosis - physiopathology
Asian Continental Ancestry Group
Blood Flow Velocity - physiology
Blood Pressure
Follow-Up Studies
Humans
Male
Middle Aged
Predictive Value of Tests
Pulsatile Flow - physiology
Risk Factors
Survival Analysis
Title Aortic pulse wave velocity predicts cardiovascular mortality in middle-aged and elderly Japanese men
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