Aortic pulse wave velocity predicts cardiovascular mortality in middle-aged and elderly Japanese men

Aortic pulse wave velocity (PWV) is widely used as a noninvasive index of arterial stiffness and was used in the present study to investigate the relationship between PWV and cardiovascular mortality in the middle-aged and elderly Japanese population using a longitudinal study design. From 1988 to 2...

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Bibliographic Details
Published in:Circulation journal : official journal of the Japanese Circulation Society Vol. 73; no. 3; p. 549
Main Authors: Inoue, Noriko, Maeda, Ryo, Kawakami, Hideshi, Shokawa, Tomoki, Yamamoto, Hideya, Ito, Chikako, Sasaki, Hideo
Format: Journal Article
Language:English
Published: Japan 2009
Subjects:
Age Distribution
Aged
Aorta - physiology
Arteriosclerosis - ethnology
Arteriosclerosis - mortality
Arteriosclerosis - physiopathology
Asian Continental Ancestry Group
Blood Flow Velocity - physiology
Blood Pressure
Follow-Up Studies
Humans
Male
Middle Aged
Predictive Value of Tests
Pulsatile Flow - physiology
Risk Factors
Survival Analysis
ISSN:1346-9843
Online Access:Get more information
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Summary:Aortic pulse wave velocity (PWV) is widely used as a noninvasive index of arterial stiffness and was used in the present study to investigate the relationship between PWV and cardiovascular mortality in the middle-aged and elderly Japanese population using a longitudinal study design. From 1988 to 2003, a total of 3,960 men (50-69 years old at baseline) who underwent medical check-ups and measurement of PWV, which was standardized for diastolic blood pressure, were recruited and divided into 4 groups according to the PWV values. The average follow-up period was 8.2 years. Mortality from all-causes and from cardiovascular disease significantly increased as PWV increased in the entire follow-up period. Multivariate-adjusted relative risks of all-cause and cardiovascular disease mortality for the highest quartile of PWV (>9.0 m/s) were 1.28 (95% confidence interval (CI) 0.97-1.68) and 1.83 (95%CI 1.02-3.29), respectively, compared with the lowest quartile (<7.5 m/s). An increased PWV can predict cardiovascular mortality in middle-aged and elderly Japanese men.
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ISSN:1346-9843
DOI:10.1253/circj.CJ-08-0492