Self-assembling bubble carriers for oral protein delivery

Successful oral delivery of therapeutic proteins such as insulin can greatly improve the quality of life of patients. This study develops a bubble carrier system by loading diethylene triamine pentaacetic acid (DTPA) dianhydride, a foaming agent (sodium bicarbonate; SBC), a surfactant (sodium dodecy...

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Vydáno v:	Biomaterials Ročník 64; s. 115 - 124
Hlavní autoři:	Chuang, Er-Yuan, Lin, Kun-Ju, Lin, Po-Yen, Chen, Hsin-Lung, Wey, Shiaw-Pyng, Mi, Fwu-Long, Hsiao, Hsu-Chan, Chen, Chiung-Tong, Sung, Hsing-Wen
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Netherlands Elsevier Ltd 01.09.2015
Témata:	absorption Administration, Oral Advanced Basic Science animal disease models Animals Biodistribution biopharmaceuticals Bubbles Capsules - toxicity Carbon dioxide Carriers Cell Line, Tumor Colloidal carrier Dentistry diabetes Diabetes Mellitus, Experimental - drug therapy Drug Carriers - toxicity epithelium foaming Foaming agent Gelatin Gelatins glycemic effect Insulin Insulin - administration & dosage Insulin - pharmacokinetics Insulin - therapeutic use Intestinal Absorption Microbubbles oral administration Oral protein delivery patients Pentetic Acid Permeability proteinase inhibitors Proteins Proteins - administration & dosage Proteolysis - drug effects quality of life Random Allocation Rats Rats, Wistar sodium bicarbonate Sodium dodecyl sulfate Sodium Dodecyl Sulfate - administration & dosage Sodium Dodecyl Sulfate - toxicity Solubility Surfactant surfactants Tablets, Enteric-Coated Tissue Distribution Tomography, Emission-Computed, Single-Photon Walls Colloidal carrier Oral protein delivery Foaming agent Surfactant Biodistribution
ISSN:	0142-9612, 1878-5905, 1878-5905
On-line přístup:	Získat plný text
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Shrnutí:	Successful oral delivery of therapeutic proteins such as insulin can greatly improve the quality of life of patients. This study develops a bubble carrier system by loading diethylene triamine pentaacetic acid (DTPA) dianhydride, a foaming agent (sodium bicarbonate; SBC), a surfactant (sodium dodecyl sulfate; SDS), and a protein drug (insulin) in an enteric-coated gelatin capsule. Following oral administration to diabetic rats, the intestinal fluid that has passed through the gelatin capsule saturates the mixture; concomitantly, DTPA dianhydride produces an acidic environment, while SBC decomposes to form CO2 bubbles at acidic pH. The gas bubbles grow among the surfactant molecules (SDS) owing to the expansion of the generated CO2. The walls of the CO2 bubbles consist of a self-assembled film of water that is in nanoscale and may serve as a colloidal carrier to transport insulin and DTPA. The grown gas bubbles continue to expand until they bump into the wall and burst, releasing their transported insulin, DTPA, and SDS into the mucosal layer. The released DTPA and SDS function as protease inhibitors to protect the insulin molecules as well as absorption enhancers to augment their epithelial permeability and eventual absorption into systemic circulation, exerting their hypoglycemic effects.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0142-9612 1878-5905 1878-5905
DOI:	10.1016/j.biomaterials.2015.06.035