Alterations of resting-state regional and network-level neural function after acute spinal cord injury

•Regional and network functional changes could be seen in the early stage of SCI.•Functional changes were associated with clinical symptom severity in SCI patients.•Functional reorganization may reflect a compensatory role in the recovery of SCI. The purpose of this study was to investigate function...

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Vydáno v:Neuroscience Ročník 277; s. 446 - 454
Hlavní autoři: Hou, J.-M., Sun, T.-S., Xiang, Z.-M., Zhang, J.-Z., Zhang, Z.-C., Zhao, M., Zhong, J.-F., Liu, J., Zhang, H., Liu, H.-L., Yan, R.-B., Li, H.-T.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Elsevier Ltd 26.09.2014
Témata:
Acute Disease
Adult
Brain - physiopathology
Brain Mapping
Female
functional MRI
functional organization
Humans
Magnetic Resonance Imaging
Male
Neural Pathways - physiopathology
Neurology
Rest
resting state
Signal Processing, Computer-Assisted
Spinal Cord Injuries - physiopathology
spinal cord injury
spinal cord injury
SMA
SMC
MNI
OFC
SPM8
fMRI
TE
functional MRI
resting state
ASIA
ALFF
FFT
SCI
functional organization
BOLD
FA
FC
DPARSF
EPI
Statistical Parametric Mapping
echo time
orbitofrontal cortex
primary sensorimotor cortex
blood oxygenation level dependent
amplitude of low-frequency fluctuations
American Spinal Cord Injury Association
data-processing assistant for resting-state
fast Fourier transform
Montreal Neurological Institute
supplementary motor area
functional connectivity
echo-planar-imaging
flip angle
functional magnetic resonance imaging
ISSN:0306-4522, 1873-7544, 1873-7544
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Popis
Shrnutí:•Regional and network functional changes could be seen in the early stage of SCI.•Functional changes were associated with clinical symptom severity in SCI patients.•Functional reorganization may reflect a compensatory role in the recovery of SCI. The purpose of this study was to investigate functional alterations of the brain in the early stage of spinal cord injury (SCI) and further investigate how these functional alterations relate to SCI patients’ sensorimotor functions. Twenty-five patients with SCI and 25 matched healthy controls underwent imaging by using resting-state functional magnetic resonance imaging (fMRI). The amplitude of low-frequency fluctuations (ALFF) were used to characterize regional neural function, and the seed-based functional connectivity (FC) was used to evaluate the functional integration of the brain network. Compared to healthy controls, patients with SCI showed decreased ALFF in the bilateral primary sensorimotor cortex, and increased ALFF in the bilateral cerebellum and right orbitofrontal cortex (OFC). The ALFF value in the left cerebellum was negatively correlated with the clinical total motor score in patients with SCI. Furthermore, SCI patients mainly showed decreased inter-hemispheric FC between the bilateral primary sensorimotor cortex, as well as increased intra-hemispheric FC within the motor network, including the primary sensorimotor cortex, premotor cortex, supplementary motor area (SMA), thalamus and cerebellum. Subsequent correlation analyses revealed that increased FC within the primary sensorimotor cortex, SMA, and cerebellum negatively correlated with the total American Spinal Cord Injury Association (ASIA) motor score. Our findings provide evidence that SCI can induce significant regional and network-level functional alterations in the early stage of the disease. We hypothesized these alterations may be an adaptive phenomenon following SCI, reflecting a compensatory mechanism during the early stage of SCI.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0306-4522
1873-7544
1873-7544
DOI:10.1016/j.neuroscience.2014.07.045