The Cameroon Mobile Phone SMS (CAMPS) Trial: A Randomized Trial of Text Messaging versus Usual Care for Adherence to Antiretroviral Therapy

Mobile phone technology is a novel way of delivering health care and improving health outcomes. This trial investigates the use of motivational mobile phone text messages (SMS) to improve adherence to antiretroviral therapy (ART) over six months. CAMPS was a single-site randomized two-arm parallel d...

Celý popis

Uložené v:
Podrobná bibliografia
Vydané v:PloS one Ročník 7; číslo 12; s. e46909
Hlavní autori: Mbuagbaw, Lawrence, Thabane, Lehana, Ongolo-Zogo, Pierre, Lester, Richard T., Mills, Edward J., Smieja, Marek, Dolovich, Lisa, Kouanfack, Charles
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Public Library of Science 06.12.2012
Public Library of Science (PLoS)
Predmet:
Acquired immune deficiency syndrome
Adhesion
Adult
Adults
AIDS
Analysis
Anti-HIV Agents - therapeutic use
Anti-Retroviral Agents - therapeutic use
Antiretroviral agents
Antiretroviral drugs
Antiretroviral therapy
Biology
Cameroon
Cell phones
Cellular telephones
Chi-square test
Clinical trials
Computer Science
Confidence intervals
Drugstores
Female
Health aspects
Health care
Health care reform
Highly active antiretroviral therapy
HIV
HIV Infections - drug therapy
HIV Seropositivity - drug therapy
Human immunodeficiency virus
Humans
Intervention
Male
Medical research
Medication Adherence
Medicine
Messages
Middle Aged
Motivation
Patient compliance
Patient Satisfaction
Pharmacy
Reminder Systems
Short message service
SMS (Short messaging service)
Social and Behavioral Sciences
Text Messaging
Therapy
Treatment Outcome
Wireless telephones
Cameroon
Ontario Canada
Canada
Vancouver British Columbia Canada
ISSN:1932-6203, 1932-6203
On-line prístup:Získať plný text
Tagy: Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
Popis
Shrnutí:Mobile phone technology is a novel way of delivering health care and improving health outcomes. This trial investigates the use of motivational mobile phone text messages (SMS) to improve adherence to antiretroviral therapy (ART) over six months. CAMPS was a single-site randomized two-arm parallel design trial in Yaoundé, Cameroon. We enrolled and randomized HIV-positive adults on ART, aged 21 years and above to receive a weekly standardized motivational text message versus usual care alone. The primary outcome was adherence measured using a visual analogue scale (VAS), number of doses missed (in the week preceding the interview) and pharmacy refill data. Outcomes were measured at 3 and 6 months. Service providers and outcome assessors were blinded to allocation. Analysis was by intention-to-treat. Between November and December 2010, 200 participants were randomized, with 101 in the intervention group and 99 in the control group. At 6 months, overall retention was 81.5%. We found no significant effect on adherence by VAS>95% (risk ratio [RR] 1.06, 95% confidence interval [CI] 0.89, 1.29; p = 0.542; reported missed doses (RR 1.01, 95% CI 0.87, 1.16; p>0.999) or number of pharmacy refills (mean difference [MD] 0.1, 95% CI: 0.23, 0.43; p = 0.617. One participant in the intervention arm reported a possible disclosure of status. Standardized motivational mobile phone text messages did not significantly improve adherence to ART in this study. Other types of messaging or longer term studies are recommended. 1. Pan-African Clinical Trials Registry; PACTR201011000261458 2. Clinicaltrials.gov; NCT01247181.
Bibliografia:ObjectType-Article-2
SourceType-Scholarly Journals-1
content type line 14
ObjectType-Feature-3
ObjectType-Evidence Based Healthcare-1
ObjectType-Article-1
ObjectType-Feature-2
content type line 23
ObjectType-Undefined-3
Competing Interests: The authors have declared that no competing interests exist.
Conceived and designed the experiments: LM LT RTL POZ EJM. Performed the experiments: LM LT CK POZ. Analyzed the data: LM LT LD MS. Contributed reagents/materials/analysis tools: LM LT. Wrote the paper: LM LT POZ MS RTL EJM LD MS.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0046909