Sequence Analysis of Six Blood Pressure Candidate Regions in 4,178 Individuals: The Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Targeted Sequencing Study

Genome-wide association studies (GWAS) identified multiple loci for blood pressure (BP) and hypertension. Six genes--ATP2B1, CACNB2, CYP17A1, JAG1, PLEKHA7, and SH2B3--were evaluated for sequence variation with large effects on systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pre...

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Veröffentlicht in:	PloS one Jg. 9; H. 10; S. e109155
Hauptverfasser:	Morrison, Alanna C., Bis, Joshua C., Hwang, Shih-Jen, Ehret, Georg B., Lumley, Thomas, Rice, Kenneth, Muzny, Donna, Gibbs, Richard A., Boerwinkle, Eric, Psaty, Bruce M., Chakravarti, Aravinda, Levy, Daniel
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 02.10.2014 Public Library of Science (PLoS)
Schlagworte:	Aging Aging - genetics Alleles Atherosclerosis Biology and Life Sciences Blood Blood pressure Blood Pressure - genetics Cardiovascular disease Cohort Studies Consortia Cytochrome Epidemiology Gene frequency Gene sequencing Genes Genetic research Genome-wide association studies Genomes Genomics Heart Heart - physiology Humans Hydroxylases Hypertension Loci Medical research Medicine Medicine and Health Sciences Polymorphism Pressure effects Sequence Analysis Single-nucleotide polymorphism Studies Variation United States > US Maryland Texas Massachusetts Baltimore Maryland
ISSN:	1932-6203, 1932-6203
Online-Zugang:	Volltext
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