ClusTRace, a bioinformatic pipeline for analyzing clusters in virus phylogenies

Background SARS-CoV-2 is the highly transmissible etiologic agent of coronavirus disease 2019 (COVID-19) and has become a global scientific and public health challenge since December 2019. Several new variants of SARS-CoV-2 have emerged globally raising concern about prevention and treatment of COVI...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:BMC bioinformatics Ročník 23; číslo 1; s. 196 - 16
Hlavní autoři: Plyusnin, Ilya, Truong Nguyen, Phuoc Thien, Sironen, Tarja, Vapalahti, Olli, Smura, Teemu, Kant, Ravi
Médium: Journal Article
Jazyk:angličtina
Vydáno: London BioMed Central 28.05.2022
BioMed Central Ltd
Springer Nature B.V
BMC
Témata:
Algorithms
Analysis
Bioinformatics
Biomedical and Life Sciences
Cladistic analysis
Cluster analysis
Computational Biology
Computational Biology/Bioinformatics
Computer Appl. in Life Sciences
Coronaviruses
Cost analysis
COVID-19
COVID-19 vaccines
DNA Viruses
Epidemics
Epidemiology
Etiology
Genetic aspects
Genomes
Health surveillance
Humans
Life Sciences
Methods
Microarrays
Mutation
Operating costs
Outliers (statistics)
Pandemics
Pathogens
Phylogenetic analysis
Phylogenetics
Phylogeny
Public health
SARS-CoV-2
SARS-CoV-2 - genetics
Severe acute respiratory syndrome coronavirus 2
Software
Trees
Variant calling
Viral diseases
Virus
Viruses
Finland
Phylogenetic analysis
Cluster analysis
Virus
SARS-CoV-2
Variant calling
ISSN:1471-2105, 1471-2105
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Background SARS-CoV-2 is the highly transmissible etiologic agent of coronavirus disease 2019 (COVID-19) and has become a global scientific and public health challenge since December 2019. Several new variants of SARS-CoV-2 have emerged globally raising concern about prevention and treatment of COVID-19. Early detection and in-depth analysis of the emerging variants allowing pre-emptive alert and mitigation efforts are thus of paramount importance. Results Here we present ClusTRace, a novel bioinformatic pipeline for a fast and scalable analysis of sequence clusters or clades in large viral phylogenies. ClusTRace offers several high-level functionalities including lineage assignment, outlier filtering, aligning, phylogenetic tree reconstruction, cluster extraction, variant calling, visualization and reporting. ClusTRace was developed as an aid for COVID-19 transmission chain tracing in Finland with the main emphasis on fast screening of phylogenies for markers of super-spreading events and other features of concern, such as high rates of cluster growth and/or accumulation of novel mutations. Conclusions ClusTRace provides an effective interface that can significantly cut down learning and operating costs related to complex bioinformatic analysis of large viral sequence sets and phylogenies. All code is freely available from https://bitbucket.org/plyusnin/clustrace/
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:1471-2105
1471-2105
DOI:10.1186/s12859-022-04709-8