Fine Epitope Mapping of the Central Immunodominant Region of Nucleoprotein from Crimean-Congo Hemorrhagic Fever Virus (CCHFV)

Crimean-Congo hemorrhagic fever (CCHF), a severe viral disease known to have occurred in over 30 countries and distinct regions, is caused by the tick-borne CCHF virus (CCHFV). Nucleocapsid protein (NP), which is encoded by the S gene, is the primary antigen detectable in infected cells. The goal of...

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Bibliographic Details
Published in:	PloS one Vol. 9; no. 11; p. e108419
Main Authors:	Liu, Dongliang, Li, Yang, Zhao, Jing, Deng, Fei, Duan, Xiaomei, Kou, Chun, Wu, Ting, Li, Yijie, Wang, Yongxing, Ma, Ji, Yang, Jianhua, Hu, Zhihong, Zhang, Fuchun, Zhang, Yujiang, Sun, Surong
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 03.11.2014 Public Library of Science (PLoS)
Subjects:	Amino Acid Sequence Animal models Animals Antibodies - blood Antibodies - immunology Antigens Biology and Life Sciences Cancer Conservation Conserved Sequence Crimean hemorrhagic fever Diagnostic systems Epitope Mapping Epitopes, B-Lymphocyte - chemistry Epitopes, B-Lymphocyte - immunology Fever Gene Expression Genetic engineering Genomes Hemorrhage Hemorrhagic Fever Virus, Crimean-Congo - genetics Hemorrhagic Fever Virus, Crimean-Congo - immunology Hemorrhagic Fever, Crimean - immunology Humans Immunodominant Epitopes - chemistry Immunodominant Epitopes - genetics Immunodominant Epitopes - immunology Immunoglobulins Laboratories Life sciences Lymphocytes B Mapping Models, Molecular Molecular Sequence Data Monoclonal antibodies Nosocomial infections Nucleocapsids Nucleoproteins - chemistry Nucleoproteins - genetics Nucleoproteins - immunology Nucleotide sequence Peptide Fragments - chemistry Peptide Fragments - genetics Peptide Fragments - immunology Peptides Protein Conformation Proteins Reagents Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology S gene Sequence Alignment Sheep Structural models Studies Three dimensional models Viral diseases Virology Viruses United States > US Texas China
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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