Retinal degeneration depends on Bmi1 function and reactivation of cell cycle proteins

The epigenetic regulator Bmi1 controls proliferation in many organs. Reexpression of cell cycle proteins such as cyclin-dependent kinases (CDKs) is a hallmark of neuronal apoptosis in neurodegenerative diseases. Here we address the potential role of Bmi1 as a key regulator of cell cycle proteins dur...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 110; no. 7; p. E593
Main Authors:	Zencak, Dusan, Schouwey, Karine, Chen, Danian, Ekström, Per, Tanger, Ellen, Bremner, Rod, van Lohuizen, Maarten, Arsenijevic, Yvan
Format:	Journal Article
Language:	English
Published:	United States 12.02.2013
Subjects:	Analysis of Variance Animals Apoptosis - physiology Cell Cycle Proteins - metabolism E2F1 Transcription Factor - metabolism Epigenesis, Genetic - genetics Epigenesis, Genetic - physiology Gene Expression Regulation - genetics Gene Expression Regulation - physiology Histological Techniques Mice Mice, Knockout Microscopy, Fluorescence Polycomb Repressive Complex 1 - genetics Polycomb Repressive Complex 1 - metabolism Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Retinal Degeneration - metabolism
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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