Metabolic syndrome and total cancer mortality in the Third National Health and Nutrition Examination Survey

Purpose Although metabolic syndrome incidence has substantially increased during the last few decades, it largely remains unclear whether this metabolic disorder is associated with total cancer mortality. The present study was carried out to investigate this important question. Methods A total of 68...

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Published in:Cancer causes & control Vol. 28; no. 2; pp. 127 - 136
Main Authors: Gathirua-Mwangi, Wambui G., Monahan, Patrick O., Murage, Mwangi J., Zhang, Jianjun
Format: Journal Article
Language:English
Published: Cham Springer Science + Business Media 01.02.2017
Springer International Publishing
Springer Nature B.V
Subjects:
Adult
Aged
Biomedical and Life Sciences
Biomedicine
Blood Glucose
Blood Pressure
Cancer Research
Databases, Factual
Epidemiology
Female
Hematology
Humans
Incidence
Lung cancer
Male
Metabolic syndrome
Metabolic Syndrome - blood
Metabolic Syndrome - mortality
Middle Aged
Mortality
Neoplasms - blood
Neoplasms - mortality
Nutrition
Nutrition Surveys
Obesity
Oncology
ORIGINAL PAPER
Prostate
Public Health
Risk Factors
Triglycerides - blood
Waist Circumference - physiology
Womens health
Young Adult
Indiana
United States > US
Indianapolis Indiana
Obesity
Metabolic syndrome
Total cancer mortality
Epidemiology
Lung cancer mortality
Non-lung cancer mortality, cohort study
ISSN:0957-5243, 1573-7225
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Summary:Purpose Although metabolic syndrome incidence has substantially increased during the last few decades, it largely remains unclear whether this metabolic disorder is associated with total cancer mortality. The present study was carried out to investigate this important question. Methods A total of 687 cancer deaths were identified from 14,916 participants in the third National Health and Nutrition Examination Survey by linking them to the National Death Index database through December 31, 2006. Cox proportional hazards regression was performed to calculate hazard ratios (HR) and 95% confidence intervals (CI) for total cancer mortality in relation to metabolic syndrome and its individual components. Results After adjustment for confounders, a diagnosis of metabolic syndrome was associated with 33% elevated total cancer mortality. Compared with individuals without metabolic syndrome, those with 3, 4 and 5 abnormal components had HRs (95% CIs) of 1.28 (1.03–1.59), 1.24 (0.96–1.60), and 1.87 (1.34–2.63), respectively ( p -trend = 0.0003). Systolic blood pressure and serum glucose were associated with an increased risk of death from total cancer [HR (95% CI) for highest vs. lowest quartiles: 1.67 (1.19–2.33), p -trend = 0.002 and 1.34 (1.04–1.74), p -trend = 0.003, respectively]. Overall null results were obtained for lung cancer mortality. The effects of metabolic syndrome and its components on non-lung cancer mortality were generally similar to, but somewhat larger than, those for total cancer mortality. Conclusion Our study is among the first to reveal that metabolic syndrome is associated with increased total cancer mortality.
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ISSN:0957-5243
1573-7225
DOI:10.1007/s10552-016-0843-1