An Early-Stage Atherosclerosis Research Model Based on Microfluidics

The arterial microenvironment plays a vital role in the pathology of atherosclerosis (AS). However, the interplay between the arterial microenvironment and atherogenesis remains unclear, partially due to the gap between cell culture and animal experiments. Addressing this problem, the present study...

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Vydáno v:Small (Weinheim an der Bergstrasse, Germany) Ročník 12; číslo 15; s. 2022 - 2034
Hlavní autoři: Zheng, Wenfu, Huang, Rong, Jiang, Bo, Zhao, Yuyun, Zhang, Wei, Jiang, Xingyu
Médium: Journal Article
Jazyk:angličtina
Vydáno: Germany Blackwell Publishing Ltd 01.04.2016
Wiley Subscription Services, Inc
Témata:
Animals
Atherosclerosis
Atherosclerosis - pathology
Biomedical Research
blood vessels
Bulging
Cellular Microenvironment
drug screening
Drugs
Endothelial cells
Experiments
Hemodynamics
Human Umbilical Vein Endothelial Cells
Humans
Hydrodynamics
Hyperglycemia - pathology
Inflammation - pathology
Laboratory animals
mechanics
Mice
microfluidic chips
Microfluidics
Microfluidics - methods
Models, Biological
Nanotechnology
Reactive Oxygen Species - metabolism
Screening
atherosclerosis
blood vessels
mechanics
microfluidic chips
drug screening
ISSN:1613-6810, 1613-6829, 1613-6829
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Shrnutí:The arterial microenvironment plays a vital role in the pathology of atherosclerosis (AS). However, the interplay between the arterial microenvironment and atherogenesis remains unclear, partially due to the gap between cell culture and animal experiments. Addressing this problem, the present study reports a microfluidic AS model reconstituting early‐stage AS. Physiological or AS‐prone hemodynamic conditions are recapitulated on the model. The on‐chip model recaptures the atherogenic responses of endothelial cells (ECs) in ways that the Petri dish could not. Significant cytotoxicity of a clinical anti‐atherosclerotic drug probucol is discovered on the model, which does not appear on Petri dish but is supported by previous clinical evidence. Moreover, the anti‐AS efficiency of platinum‐nanoparticles (Pt‐NPs) on the model shows excellent consistency with animal experiments. The early‐stage AS model shows an excellent connection between Petri dish and animal experiments and highlights its promising role in bridging fundamental AS research, drug screening, and clinical trials. An early‐stage atherosclerosis (AS) research model based on a microfluidic chip is reported. AS‐prone hemodynamic conditions are recapitulated on the model, which recaptures the atherogenic responses of endothelial cells that could not be realized on a Petri dish. The early‐stage AS model shows an excellent connection between the Petri dish and animal experiments and highlights its promising role in bridging fundamental AS research, drug screening, and clinical trials.
Bibliografie:CAS/SAFEA International Partnership Program for Creative Research Teams
Ministry of Science and Technology of China - No. 2011CB933201
ark:/67375/WNG-K0TP3PLB-M
National Science Foundation of China - No. 31170905; No. 81361140345; No. 31470911; No. 51373043
istex:C5174E045577DED69465689932A0CB3A105B7713
ArticleID:SMLL201503241
"Strategic Priority Research Program" of the Chinese Academy of Sciences - No. XDA09030305; No. XDA09030307
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ISSN:1613-6810
1613-6829
1613-6829
DOI:10.1002/smll.201503241