Progressive multifocal leukoencephalopathy in a lung transplant recipient: Isolation of John Cunningham (JC) virus from bronchoalveolar lavage

Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by polyomavirus John Cunningham (JC) virus. We report the case of a 60-year-old woman who presented 16 months after right single lung transplant with worsening memory, behavioral problems...

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Veröffentlicht in:Journal of global infectious diseases Jg. 8; H. 1; S. 51 - 54
Hauptverfasser: Panchabhai, TanmayS, Choudhary, Chirag, Isada, Carlos, Folch, Erik, Mehta, AtulC
Format: Journal Article
Sprache:Englisch
Veröffentlicht: India Medknow Publications and Media Pvt. Ltd 2016
Medknow Publications & Media Pvt. Ltd
Medknow Publications & Media Pvt Ltd
Wolters Kluwer Medknow Publications
Schlagworte:
Acquired immunodeficiency syndrome
Case Report
Case studies
Central nervous system
Health aspects
John Cunningham virus
lung transplant
Lung transplantation
Progressive multifocal leukoencephalopathy
Virus diseases
John Cunningham virus
lung transplant
progressive multifocal leukoencephalopathy
Acquired immunodeficiency syndrome
ISSN:0974-777X, 0974-8245
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Zusammenfassung:Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by polyomavirus John Cunningham (JC) virus. We report the case of a 60-year-old woman who presented 16 months after right single lung transplant with worsening memory, behavioral problems, emotional lability, and progressive left upper extremity weakness. Magnetic resonance imaging revealed white matter changes suggestive of PML. JC virus infection was confirmed with polymerase chain reaction (PCR) from both the bronchoalveolar lavage (BAL) fluid and cerebrospinal fluid. To our knowledge, this is the first report of PCR isolation of JC virus from a BAL specimen. We also review the two additional cases in the literature that describe PML after lung transplantation. JC virus infection should be considered in the differential diagnosis of lung transplant recipients who develop neurological symptoms. BAL may have a role in the etiologic diagnosis of PML after lung transplantation.
Bibliographie:ObjectType-Article-1
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ISSN:0974-777X
0974-8245
DOI:10.4103/0974-777X.176150