The role of the gut microbiome and its metabolites in metabolic diseases

It is well known that an unhealthy lifestyle is a major risk factor for metabolic diseases, while in recent years, accumulating evidence has demonstrated that the gut microbiome and its metabolites also play a crucial role in the onset and development of many metabolic diseases, including obesity, t...

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Vydáno v:	Protein & cell Ročník 12; číslo 5; s. 360 - 373
Hlavní autoři:	Wu, Jiayu, Wang, Kai, Wang, Xuemei, Pang, Yanli, Jiang, Changtao
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Beijing Higher Education Press 01.05.2021 Springer Nature B.V
Témata:	Biochemistry Biomedical and Life Sciences Cardiovascular diseases Cardiovascular Diseases - microbiology Cell Biology Developmental Biology Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - microbiology Diet Digestive system Fatty liver Gastrointestinal Microbiome Gastrointestinal tract gut microbiome Gut microbiota Human Genetics Humans immune regulation Immune response Intestinal microflora Life Sciences Liver diseases metabolic diseases Metabolic disorders Metabolic pathways metabolism metabolite Metabolites Microbiomes Microbiota Non-alcoholic Fatty Liver Disease - microbiology Nutrients Obesity - microbiology Protein Science Review Risk factors Stem Cells metabolism gut microbiome metabolite metabolic diseases immune regulation
ISSN:	1674-800X, 1674-8018, 1674-8018
On-line přístup:	Získat plný text
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Popis
Shrnutí:	It is well known that an unhealthy lifestyle is a major risk factor for metabolic diseases, while in recent years, accumulating evidence has demonstrated that the gut microbiome and its metabolites also play a crucial role in the onset and development of many metabolic diseases, including obesity, type 2 diabetes, nonalcoholic fatty liver disease, cardiovascular disease and so on. Numerous microorganisms dwell in the gastrointestinal tract, which is a key interface for energy acquisition and can metabolize dietary nutrients into many bioactive substances, thus acting as a link between the gut microbiome and its host. The gut microbiome is shaped by host genetics, immune responses and dietary factors. The metabolic and immune potential of the gut microbiome determines its significance in host health and diseases. Therefore, targeting the gut microbiome and relevant metabolic pathways would be effective therapeutic treatments for many metabolic diseases in the near future. This review will summarize information about the role of the gut microbiome in organism metabolism and the relationship between gut microbiome-derived metabolites and the pathogenesis of many metabolic diseases. Furthermore, recent advances in improving metabolic diseases by regulating the gut microbiome will be discussed.
Bibliografie:	gut microbiome metabolite Document received on :2020-05-03 metabolic diseases metabolism Document accepted on :2020-11-10 immune regulation ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	1674-800X 1674-8018 1674-8018
DOI:	10.1007/s13238-020-00814-7