Impact of Historic Migrations and Evolutionary Processes on Human Immunity

The evolution of mankind has constantly been influenced by the pathogens encountered. The various populations of modern humans that ventured out of Africa adapted to different environments and faced a large variety of infectious agents, resulting in local adaptations of the immune system for these p...

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Bibliographic Details
Published in:	Trends in immunology Vol. 40; no. 12; pp. 1105 - 1119
Main Authors:	Domínguez-Andrés, Jorge, Netea, Mihai G.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.12.2019 Elsevier Limited
Subjects:	Adaptation Antigens Autoimmune diseases Autoimmune Diseases - genetics Autoimmune Diseases - immunology Bacteria Bacterial infections Biological Evolution Communicable Diseases - genetics Communicable Diseases - immunology Evolution Evolutionary genetics Genes Genetic Predisposition to Disease Genetics, Population Genomes Hemoglobin Host-Pathogen Interactions Human Migration Humans Immune system immunity Immunity - genetics Infections Infectious diseases Inflammatory diseases Malaria Microorganisms migrations Pathogens Proteins selective pressure Tuberculosis Viral infections Western World West Africa Africa autoimmune diseases selective pressure evolution immunity pathogens migrations
ISSN:	1471-4906, 1471-4981, 1471-4981
Online Access:	Get full text
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