Ferroptosis, radiotherapy, and combination therapeutic strategies

Ferroptosis, an iron-dependent form of regulated cell death driven by peroxidative damages of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes, has recently been revealed to play an important role in radiotherapy-induced cell death and tumor suppression, and to mediate the s...

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Podrobná bibliografie
Vydáno v:	Protein & cell Ročník 12; číslo 11; s. 836 - 857
Hlavní autoři:	Lei, Guang, Mao, Chao, Yan, Yuelong, Zhuang, Li, Gan, Boyi
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Beijing Higher Education Press 01.11.2021 Springer Nature B.V
Témata:	Apoptosis Biochemistry Biomedical and Life Sciences Cell Biology Cell death Cell membranes combination therapy Developmental Biology Ferroptosis Ferroptosis - immunology GPX4 Human Genetics Humans Immunotherapy Life Sciences lipid peroxidation Neoplasms - immunology Neoplasms - therapy Phospholipids Polyunsaturated fatty acids Protein Science Radiation therapy radiosensitization Radiotherapy Review SLC7A11 Stem Cells Tumor suppression Tumors ferroptosis GPX4 immunotherapy radiosensitization radiotherapy combination therapy SLC7A11 lipid peroxidation
ISSN:	1674-800X, 1674-8018, 1674-8018
On-line přístup:	Získat plný text
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Popis
Shrnutí:	Ferroptosis, an iron-dependent form of regulated cell death driven by peroxidative damages of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes, has recently been revealed to play an important role in radiotherapy-induced cell death and tumor suppression, and to mediate the synergy between radiotherapy and immunotherapy. In this review, we summarize known as well as putative mechanisms underlying the crosstalk between radiotherapy and ferroptosis, discuss the interactions between ferroptosis and other forms of regulated cell death induced by radiotherapy, and explore combination therapeutic strategies targeting ferroptosis in radiotherapy and immunotherapy. This review will provide important frameworks for future investigations of ferroptosis in cancer therapy.
Bibliografie:	Document accepted on :2021-03-29 ferroptosis GPX4 immunotherapy radiosensitization Document received on :2021-02-18 radiotherapy combination therapy SLC7A11 lipid peroxidation ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	1674-800X 1674-8018 1674-8018
DOI:	10.1007/s13238-021-00841-y