Prognostication and treatment predictions for estrogen receptor positive early-stage breast cancer: incorporating the 70-gene signature into the PREDICT prognostication model

The 70-gene signature (70-GS) has been shown to identify women at low-risk of distant recurrence who can safely forgo adjuvant chemotherapy. Incorporating this GS into the well-validated and widely used PREDICT breast cancer model could improve the model's ability to estimate breast cancer prog...

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Bibliographic Details
Published in:	Breast (Edinburgh) Vol. 83; p. 104542
Main Authors:	Engelhardt, Ellen G., Binuya, Mary Ann E., Pharoah, Paul D.P., Poncet, Coralie, Rutgers, Emiel J.T., Piccart, Martine, Cardoso, Fatima, van ‘t Veer, Laura J., Steyerberg, Ewout W., Linn, Sabine C., Schmidt, Marjanka K.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01.10.2025 Elsevier
Subjects:	70-Gene signature Adult Aged Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - mortality Breast Neoplasms - pathology Breast Neoplasms - therapy Chemotherapy, Adjuvant Female Gene Expression Profiling Hematology, Oncology, and Palliative Medicine Humans Middle Aged Model extension Neoplasm Recurrence, Local - genetics Neoplasm Staging Netherlands Original PREDICT for breast cancer model Predictive Value of Tests Prognosis Prognostication Receptors, Estrogen - metabolism Registries Risk Assessment - methods Transcriptome Validation Netherlands Validation 70-Gene signature Prognostication Model extension PREDICT for breast cancer model
ISSN:	0960-9776, 1532-3080, 1532-3080
Online Access:	Get full text
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