Different doses of methamphetamine alter long-term potentiation, level of BDNF and neuronal apoptosis in the hippocampus of reinstated rats

Methamphetamine (METH) is a psychostimulant. The precise mechanisms of its effects remain unknown and current relapse treatments have low efficacy. However, brain-derived neurotrophic factor (BDNF) and neuronal plasticity are essential contributors, despite paradoxical reports and a lack of comprehe...

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Veröffentlicht in:	The journal of physiological sciences Jg. 69; H. 2; S. 409 - 419
Hauptverfasser:	Shahidi, Siamak, Komaki, Alireza, Sadeghian, Reihaneh, Asl, Sara Soleimani
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Japan Elsevier Inc 01.03.2019 BioMed Central Springer Japan
Schlagworte:	Addictions Animals Antibodies Apoptosis Apoptosis - drug effects Brain derived neurotrophic factor Brain-Derived Neurotrophic Factor - metabolism Central Nervous System Stimulants - pharmacology Conditioned place preference Drug dosages Electrophysiology Extinction FDA approval Hippocampus Hippocampus - drug effects Laboratory animals Long-term potentiation Long-Term Potentiation - drug effects Male Methamphetamine Methamphetamine - pharmacology Neurobiology Neuronal apoptosis Neuronal Plasticity - drug effects Neuroplasticity Original Paper Place preference conditioning Proteins Rats Rats, Wistar Reinstatement Software Synaptic plasticity Variance analysis Western blotting United States > US Neuronal apoptosis Brain derived neurotrophic factor Conditioned place preference Reinstatement Long-term potentiation Methamphetamine
ISSN:	1880-6546, 1880-6562, 1880-6562
Online-Zugang:	Volltext
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