LGI1-ADAM22-MAGUK configures transsynaptic nanoalignment for synaptic transmission and epilepsy prevention

Physiological functioning and homeostasis of the brain rely on finely tuned synaptic transmission, which involves nanoscale alignment between presynaptic neurotransmitter-release machinery and postsynaptic receptors. However, the molecular identity and physiological significance of transsynaptic nan...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 118; H. 3
Hauptverfasser:	Fukata, Yuko, Chen, Xiumin, Chiken, Satomi, Hirano, Yoko, Yamagata, Atsushi, Inahashi, Hiroki, Sanbo, Makoto, Sano, Hiromi, Goto, Teppei, Hirabayashi, Masumi, Kornau, Hans-Christian, Prüss, Harald, Nambu, Atsushi, Fukai, Shuya, Nicoll, Roger A, Fukata, Masaki
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 19.01.2021
Schlagworte:	ADAM Proteins - genetics Animals Brain - metabolism Brain - pathology Calcium-Binding Proteins - genetics Disease Models, Animal Epilepsy - genetics Epilepsy - pathology Epilepsy - prevention & control Gene Knock-In Techniques Guanylate Kinases - genetics Hippocampus - metabolism Hippocampus - pathology Humans Intracellular Signaling Peptides and Proteins - genetics Membrane Proteins - genetics Mice Nerve Tissue Proteins - genetics Neural Cell Adhesion Molecules - genetics Receptors, AMPA - genetics Receptors, N-Methyl-D-Aspartate - genetics Shaker Superfamily of Potassium Channels - genetics Synaptic Transmission - genetics epilepsy LGI1–ADAM22 AMPA receptor MAGUK transsynaptic nanocolumn
ISSN:	1091-6490, 1091-6490
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