The subgingival periodontal microbiota of the aging mouth

Different mechanisms have been hypothesized to explain the increase in prevalence and severity of periodontitis in older adults, including shifts in the periodontal microbiota. However, the actual impact of aging on the composition of subgingival biofilms remains unclear. In the present article, we...

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Vydáno v:Periodontology 2000 Ročník 72; číslo 1; s. 30 - 53
Hlavní autoři: Feres, Magda, Teles, Flavia, Teles, Ricardo, Figueiredo, Luciene Cristina, Faveri, Marcelo
Médium: Journal Article
Jazyk:angličtina
Vydáno: Denmark Blackwell Publishing Ltd 01.10.2016
Témata:
Adult
Aged
Aged, 80 and over
Aging - physiology
Alzheimer Disease - complications
Bacteria - classification
Bacteria - pathogenicity
Biofilms
Gingival Pocket - microbiology
Host-Pathogen Interactions - immunology
Host-Pathogen Interactions - physiology
Humans
Immunosenescence
Microbiota
Middle Aged
Mouth - microbiology
Periodontal Pocket - microbiology
Periodontitis - complications
Periodontitis - microbiology
Periodontium - microbiology
Time Factors
ISSN:0906-6713, 1600-0757
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Popis
Shrnutí:Different mechanisms have been hypothesized to explain the increase in prevalence and severity of periodontitis in older adults, including shifts in the periodontal microbiota. However, the actual impact of aging on the composition of subgingival biofilms remains unclear. In the present article, we provide an overview of the composition of the subgingival biofilm in older adults and the potential effects of age on the oral microbiome. In particular, this review covers the following topics: (i) the oral microbiota of an aging mouth; (ii) the effects of age and time on the human oral microbiome; (iii) the potential impact of inflammaging and immunosenescence in the host–oral microbiota interactions; and (iv) the relationship of the aging oral microbiota and Alzheimer's disease. Finally, we present analyses of data compiled from large clinical studies that evaluated the subgingival microbiota of periodontally healthy subjects and patients with periodontitis from a wide age spectrum (20–83 years of age).
Bibliografie:National Institute of Dental and Craniofacial Research - No. 5 R03 TW006269-02; No. 1 R01 DE024767-01
São Paulo Research Foundation - No. 2007/56413-0; No. 2007/55291-9; No. 2009/17677-8; No. 2010/10384-2; No. 2011/23034-2
ArticleID:PRD12136
istex:E5AD411917DEAF6DFD196CE0CA9471B995B0599A
The National Council for Scientific and Technological Development - No. 304887/2013-7; No. 309015/2012-0; No. 308124/2013-8
ark:/67375/WNG-S41DP76G-2
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ISSN:0906-6713
1600-0757
DOI:10.1111/prd.12136