Localized delivery of therapeutic doxorubicin dose across the canine blood-brain barrier with hyperthermia and temperature sensitive liposomes

Most drugs cannot penetrate the blood-brain barrier (BBB), greatly limiting the use of anti-cancer agents for brain cancer therapy. Temperature sensitive liposomes (TSL) are nanoparticles that rapidly release the contained drug in response to hyperthermia (>40 °C). Since hyperthermia also transie...

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Bibliographic Details
Published in:	Drug delivery Vol. 25; no. 1; pp. 973 - 984
Main Authors:	Bredlau, Amy Lee, Motamarry, Anjan, Chen, Chao, McCrackin, M. A., Helke, Kris, Armeson, Kent E., Bynum, Katrina, Broome, Ann-Marie, Haemmerich, Dieter
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis 01.11.2018 Taylor & Francis Ltd Taylor & Francis Group
Subjects:	blood-brain barrier Brain cancer doxorubicin Drug dosages Fever Hyperthermia liposomes Microscopy thermal therapy Thermosensitive liposomes Thermosensitive liposomes hyperthermia blood–brain barrier doxorubicin thermal therapy liposomes
ISSN:	1071-7544, 1521-0464, 1521-0464
Online Access:	Get full text
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