Cognitive Function and Ophthalmological Diseases: The Beijing Eye Study

To examine associations between cognitive function and ophthalmological parameters, the population-based Beijing Eye Study examined ophthalmologically and physically 3127 individuals (mean age: 64.2 ± 9.8 years). Using the mini–mental state examination, cognitive function was assessed as cognitive f...

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Published in:Scientific reports Vol. 8; no. 1; pp. 4816 - 11
Main Authors: Jonas, Jost B., Wei, Wen Bin, Zhu, Li Ping, Xu, Liang, Wang, Ya Xing
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 19.03.2018
Nature Publishing Group
Subjects:
692/617/375/132/1283
692/699/3161/3174
Acuity
Age
Cataracts
Cognitive ability
Diabetes mellitus
Diabetic retinopathy
Geriatrics
Glaucoma
Humanities and Social Sciences
Macular degeneration
multidisciplinary
Multivariate analysis
Population studies
Retina
Retinopathy
Science
Science (multidisciplinary)
Visual perception
Beijing China
China
ISSN:2045-2322, 2045-2322
Online Access:Get full text
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Summary:To examine associations between cognitive function and ophthalmological parameters, the population-based Beijing Eye Study examined ophthalmologically and physically 3127 individuals (mean age: 64.2 ± 9.8 years). Using the mini–mental state examination, cognitive function was assessed as cognitive function score (CFS). Mean CFS was 26.3 ± 3.7 (median: 27; range: 2–30). Prevalence of mild (CFS: 23–19), moderate (CFS: 18–10) and severe cognitive dysfunction was 9.6% (95% confidence interval (CI): 8.5, 10.6), 3.2% (95% CI: 2.6, 3.9) and 0.6% (95% CI: 0.4,0.9), respectively. In multivariate analysis, better cognition (i.e., higher CFS) was significantly associated with better best corrected visual acuity (r 2  = 0.38), smaller amount of undercorrected visual acuity, lower prevalence of primary angle-closure glaucoma, and thicker subfoveal choroidal thickness. Prevalence of age-related macular degeneration, open-angle glaucoma, diabetic retinopathy, any type of cataract, retinal vein occlusions or pseudoexfoliation was not significantly correlated with CFS. Though the causal relationship is unclear, the associations of lower cognitive function with undercorrected visual acuity suggest the need for earlier and more regular refraction testing in the elderly so that providing adequate glasses to the elderly can be provided and vision-associated cognitive decline can be reduced. Associations of cognitive function with primary angle-closure glaucoma and leptochoroid should be further explored.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-23314-5