Functional connectivity in the default network during resting state is preserved in a vegetative but not in a brain dead patient

Recent studies on spontaneous fluctuations in the functional MRI blood oxygen level‐dependent (BOLD) signal in awake healthy subjects showed the presence of coherent fluctuations among functionally defined neuroanatomical networks. However, the functional significance of these spontaneous BOLD fluct...

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Vydáno v:	Human brain mapping Ročník 30; číslo 8; s. 2393 - 2400
Hlavní autoři:	Boly, M., Tshibanda, L., Vanhaudenhuyse, A., Noirhomme, Q., Schnakers, C., Ledoux, D., Boveroux, P., Garweg, C., Lambermont, B., Phillips, C., Luxen, A., Moonen, G., Bassetti, C., Maquet, P., Laureys, S.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.08.2009 Wiley-Liss Wiley Liss, Inc
Témata:	Adult Biological and medical sciences Brain - physiopathology Brain Death - physiopathology Brain Mapping consciousness default network Electrodiagnosis. Electric activity recording Female Frontal Lobe - physiopathology functional MRI Gyrus Cinguli - physiopathology Human health sciences Humans Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging Male Medical sciences Middle Aged Nervous system Neural Pathways - physiopathology Neurologie Neurology Persistent Vegetative State - physiopathology Radiodiagnosis. Nmr imagery. Nmr spectrometry Rest - physiology resting state Sciences de la santé humaine Thalamus - physiopathology vegetative state Coma Human Nervous system diseases Radiodiagnosis consciousness Consciousness impairment Brain death Vegetative state default network Nuclear magnetic resonance imaging functional MRI resting state Neurological disorder
ISSN:	1065-9471, 1097-0193, 1097-0193
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Shrnutí:	Recent studies on spontaneous fluctuations in the functional MRI blood oxygen level‐dependent (BOLD) signal in awake healthy subjects showed the presence of coherent fluctuations among functionally defined neuroanatomical networks. However, the functional significance of these spontaneous BOLD fluctuations remains poorly understood. By means of 3 T functional MRI, we demonstrate absent cortico‐thalamic BOLD functional connectivity (i.e. between posterior cingulate/precuneal cortex and medial thalamus), but preserved cortico‐cortical connectivity within the default network in a case of vegetative state (VS) studied 2.5 years following cardio‐respiratory arrest, as documented by extensive behavioral and paraclinical assessments. In the VS patient, as in age‐matched controls, anticorrelations could also be observed between posterior cingulate/precuneus and a previously identified task‐positive cortical network. Both correlations and anticorrelations were significantly reduced in VS as compared to controls. A similar approach in a brain dead patient did not show any such long‐distance functional connectivity. We conclude that some slow coherent BOLD fluctuations previously identified in healthy awake human brain can be found in alive but unaware patients, and are thus unlikely to be uniquely due to ongoing modifications of conscious thoughts. Future studies are needed to give a full characterization of default network connectivity in the VS patients population. Hum Brain Mapp, 2009. © 2009 Wiley‐Liss, Inc.
Bibliografie:	istex:43A61D0029371F2346E492CDA9CE450A67B1B941 Centre Hospitalier Universitaire Sart Tilman ArticleID:HBM20672 Fondation Médicale Reine Elisabeth McDonnell Foundation Belgian Fonds National de la Recherche Scientifique (FNRS) - No. 3.4517.04 University of Liège European Commission Concerted Research Action from Belgian French Community - No. ARC 06/11-340 ark:/67375/WNG-09HZNPK9-D Mind Science Foundation ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 scopus-id:2-s2.0-67650480164
ISSN:	1065-9471 1097-0193 1097-0193
DOI:	10.1002/hbm.20672