Unique metabolic activation of adipose tissue macrophages in obesity promotes inflammatory responses

Aims/hypothesis Recent studies have identified intracellular metabolism as a fundamental determinant of macrophage function. In obesity, proinflammatory macrophages accumulate in adipose tissue and trigger chronic low-grade inflammation, that promotes the development of systemic insulin resistance,...

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Bibliographic Details
Published in:	Diabetologia Vol. 61; no. 4; pp. 942 - 953
Main Authors:	Boutens, Lily, Hooiveld, Guido J., Dhingra, Sourabh, Cramer, Robert A., Netea, Mihai G., Stienstra, Rinke
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2018 Springer Nature B.V
Subjects:	Activation, Metabolic Adipocytes - metabolism Adipose tissue Adipose Tissue - cytology Animals Bone marrow CD14 antigen Cell activation Chair Nutrition Metabolism and Genomics Cytokines Cytokines - metabolism Diabetes mellitus DNA microarrays Energy metabolism Enzyme-linked immunosorbent assay Explants Gene expression Gene Expression Profiling Gene Expression Regulation Glycolysis HNE Nutrition, Metabolism and Genomics HNE Voeding, Metabolisme en Genomics Human Physiology Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-inducible factor 1a Inflammation Insulin Insulin Resistance Internal Medicine Intracellular Lactic acid Leptin Macrophages Macrophages - metabolism Male Medicine Medicine & Public Health Metabolic activation Metabolic Diseases Metabolic rate Metabolism Mice Mice, Inbred C57BL Mice, Knockout Myeloid Cells - cytology Nutrition, Metabolism and Genomics Obesity Obesity - metabolism Oxidation Oxidative phosphorylation Oxygen - chemistry Peritoneum Phenotype VLAG Voeding, Metabolisme en Genomica Immunometabolism Inflammation Adipose tissue Glycolysis obesity Oxidative phosphorylation Macrophages
ISSN:	0012-186X, 1432-0428, 1432-0428
Online Access:	Get full text
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